Evidence map›Paper›PMID 33957727›Full record

ArticleTurkish journal of medical sciences2021

Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?

Gülsüm Akgün Çağlıyan, Sibel Hacıoğlu, Başak Ünver Koluman, Kadir İlkkılıç, Rukiye Nar, Mehmet Nuri Başer, Aslı Bozdemir, Hande Şenol, Nilay Şen Türk, Veysel Erol and 3 more

Abstract read
In one paragraph

Article in Turkish journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gülsüm Akgün ÇağlıyanDepartment of Hematology, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0002-2073-1949
Sibel HacıoğluDepartment of Hematology, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0003-0757-9206
Başak Ünver KolumanDepartment of Hematology, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0003-1106-5021
Kadir İlkkılıçDepartment of Hematology, Recep Tayyip Erdogan University Traning and Research Hospital, Rize, TurkeyORCID 0000-0003-1136-0514
Rukiye NarDepartment of Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0002-1062-0217
Mehmet Nuri BaşerDepartment of Internal Medicine, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0003-1809-5581
Aslı BozdemirDepartment of Internal Medicine, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0002-3886-8900
Hande ŞenolDepartment of Biostatistics, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0001-6395-7924
Nilay Şen TürkDepartment of Pathology, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0002-8294-558X
Veysel ErolDepartment of Hematology, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0001-5244-3733
Onurcan YılıdırımDepartment of Internal Medicine, Şemdinli State Hospital, Hakkari, TurkeyORCID 0000-0002-2794-1746
Ömer ÇağlıyanDepartment of Cardiology, Denizli State Hospital, Denizli, TurkeyORCID 0000-0002-4484-0357
Nil GülerDepartment of Hematology, Faculty of Medicine, Pamukkale University, Denizli, TurkeyORCID 0000-0003-0604-6475

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1–190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high (≥ 2) or low (< 2) CONUT scores in terms of overall survival (OS) and progression-free survival (PFS). The 5-year OS and PFS in patients with high CONUT score was 52.1% and 49.7%. The 5-year OS and PFS in patients with low CONUT score was 79.8% and 75.6% (p < 0.001). In the multivariate analysis for OS, age ≥ 65 years (HR = 1.80, p = 0.028), Eastern Cooperative Oncology Group (ECOG) > 1 (HR = 2.04, p = 0.006), stage IIIA–IVB disease (HR = 2.75, p = 0.001) and the CONUT score (HR = 1.15, p = 0.003) were found statistically significant. In the multivariate analysis for PFS, age ≥ 65 years (HR = 2.02, p = 0.007), stage IIIA–IVB disease (HR = 2.42, p = 0.002) and the CONUT score (HR = 1.19, p = 0.001) were found to be significant parameters. Conclusion: High CONUT score reduces OS and PFS in DLBCL. CONUT score is an independent, strong prognostic index in patients with DLBCL.

Indexed as

AdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansLymphocytesLymphoma, Large B-Cell, DiffuseMaleMiddle AgedNutritional StatusPrognosisRetrospective StudiesSurvivalControlling Nutritional Status scoreLymphomaprognosissurvival

Identifiers

PMID33957727
PMCPMC8569763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.