Evidence map›Paper›PMID 33957715›Full record

ArticleInternational neurourology journal2021

Interplay Between Cognitive and Bowel/Bladder Function in Multiple Sclerosis.

Antonio Carotenuto, Teresa Costabile, Marcello Moccia, Fabrizia Falco, Maria Petracca, Barbara Satelliti, Cinzia Valeria Russo, Francesco Saccà, Roberta Lanzillo, Vincenzo Brescia Morra

Open access · diamondAbstract read
In one paragraph

Article in International neurourology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Neurogenic bladder in the multiple sclerosis population: A systematic review and meta-analysis of prevalence and a proposed evaluation algorithm.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Antonio CarotenutoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Teresa CostabileDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Marcello MocciaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Fabrizia FalcoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Maria PetraccaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Barbara SatellitiDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Cinzia Valeria RussoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Francesco SaccàDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Roberta LanzilloDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Vincenzo Brescia MorraDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
Federico II University Hospital · IT

Funding

AlmirallECTRIMS-MAGNIMS SocietyMerckNovartisUK MS Society
6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate the prevalence of bowel/bladder dysfunction in multiple sclerosis (MS) and its associations with cognitive impairment.

methodsWe prospectively enrolled 150 MS patients. Patients were administered the Symbol Digit Modality Test (SDMT), the Neurogenic Bowel Dysfunction Score (NBDS), and the Actionable Bladder Symptom Screening Tool (ABSST). The associations between bowel/bladder dysfunction and cognitive function were assessed through hierarchical regression models using the SDMT and clinicodemographic features as independent variables and NBDS and ABSST scores as dependent variables.

resultsThe prevalence of bowel/bladder deficits was 44.7%, with 26 patients (17.3%) suffering from bowel deficits and 60 patients (40%) from bladder deficits. The total NBDS and ABSST scores were correlated with the SDMT (β=-0.10, P<0.001 and β=-0.03, P=0.04, respectively) after correction for demographic features and physical disability.

conclusionBowel/bladder disorders are common in MS and are associated with both physical and cognitive disability burdens. As SDMT is embedded into routine clinical assessments, a lower score may warrant investigating bowel/bladder dysfunction due to the strong interplay of these factors.

Indexed as

BladderBowelCognitionDisabilityPatient-Reported Outcome

Identifiers

PMID33957715
PMCPMC8748300
OpenAlexW3157867457

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.