ArticleNeurobiology of aging2021
Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.
Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances.Signal transduction and targeted therapy · 2025Review
- Association of Plasma Biomarkers of Alzheimer Disease and Neurodegeneration With Longitudinal Intra-Network Functional Brain Connectivity.Neurology · 2025Article
- Connectome-based prediction of future episodic memory performance for individual amnestic mild cognitive impairment patients.Brain communications · 2025Article
- Brain activity dynamics after traumatic brain injury indicate increased state transition energy and preference of lower order states.NeuroImage. Clinical · 2025Article
- Proteomic Indicators of Health Predict Alzheimer's Disease Biomarker Levels and Dementia Risk.Annals of neurology · 2024Article
- Sex differences in default mode network connectivity in healthy aging adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Past and future episodic detail retrieval is reduced among clinically normal older adults at higher genetic risk for late-onset Alzheimer's disease.Neuropsychology · 2023Article
- Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers.Neurobiology of aging · 2022Article
- APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.PLoS biology · 2022Article
- Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma Biomarkers.Neurology · 2022Article
- Accelerated decline in white matter microstructure in subsequently impaired older adults and its relationship with cognitive decline.Brain communications · 2022Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The default mode network (DMN) overlaps with regions showing early Alzheimer's Disease (AD) pathology. Age, sex, and apolipoprotein E ɛ4 are the predominant risk factors for developing AD. How these risk factors interact to influence DMN connectivity and connectivity-cognition relationships before the onset of impairment remains unknown. Here, we examined these issues in 475 cognitively normal adults, targeting total DMN connectivity, its anticorrelated network (acDMN), and the DMN-hippocampal component. There were four main findings. First, in the ɛ3 homozygous group, lower DMN and acDMN connectivity was observed with age. Second, sex and ɛ4 modified the relationship between age and connectivity for the DMN and hippocampus with ɛ4 vs. ɛ3 males showing sustained or higher connectivity with age. Third, in the ɛ3 group, age and sex modified connectivity-cognition relationships with the oldest participants having the most differential patterns due to sex. Fourth, ɛ4 carriers with lower connectivity had poorer cognitive performance. Taken together, our results show the three predominant risk factors for AD interact to influence brain function and function-cognition relationships.
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