Evidence map›Paper›PMID 33957173›Full record

ReviewFrontiers in neuroendocrinology2021

Role of microbes in the pathogenesis of neuropsychiatric disorders.

Aranyak Goswami, Frank R Wendt, Gita A Pathak, Daniel S Tylee, Flavio De Angelis, Antonella De Lillo, Renato Polimanti

Abstract readReview
In one paragraph

Review in Frontiers in neuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Microbes and Mental Illness: Past, Present, and Future.Healthcare (Basel, Switzerland) · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. The Microbiome-Gut-Brain Axis and Dementia: A Bibliometric Analysis.International journal of environmental research and public health · 2022
    Article
  8. The Impact of ProbioticAnimals : an open access journal from MDPI · 2022
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aranyak GoswamiDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.
Frank R WendtDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.
Gita A PathakDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.
Daniel S TyleeDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.
Flavio De AngelisDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.
Antonella De LilloDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.
Renato PolimantiDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA. Electronic address: renato.polimanti@yale.edu.

Funding

Genome-wide Investigation of the Interplay Between Age-Related Hearing Loss and Smoking BehaviorsR21DC018098 · NIDCD · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2019 to 2021
$440k
Investigating the Systems Genetics of the Patterns of Polysubstance Abuse and AddictionR21DA047527 · NIDA · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2019 to 2020
$369k
Decoding the Sex-Specific Biological Mechanisms of Psychiatric Disorders Using Genome-Wide AnalysesF32MH122058 · NIMH · YALE UNIVERSITY · PI WENDT, FRANK · 2020 to 2021
$118k
NIDA NIH HHS R21 DA047527NIDCD NIH HHS R21 DC018098NIMH NIH HHS F32 MH122058
6 · The paper itself

Abstract

Microbes inhabit different anatomical sites of the human body including oral cavity, gut, and skin. A growing literature highlights how microbiome variation is associated with human health and disease. There is strong evidence of bidirectional communication between gut and brain mediated by neurotransmitters and microbial metabolites. Here, we review the potential involvement of microbes residing in the gut and in other body sites in the pathogenesis of eight neuropsychiatric disorders, discussing findings from animal and human studies. The data reported provide a comprehensive overview of the current state of the microbiome research in neuropsychiatry, including hypotheses about the mechanisms underlying the associations reported and the translational potential of probiotics and prebiotics.

Indexed as

Gastrointestinal MicrobiomeProbioticsAnimalsBrainHumansPrebioticsPrebioticsDysbiosisGut-brain- axisInflammationMicrobiomeNeuropsychiatric disordersProbiotics

Identifiers

PMID33957173
PMCPMC8364482

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.