Evidence map›Paper›PMID 33957073›Full record

ArticleNeuron2021

Building brain capital.

Harris A Eyre, Rym Ayadi, William Ellsworth, Gowri Aragam, Erin Smith, Walter D Dawson, Agustin Ibanez, Cara Altimus, Michael Berk, Husseini K Manji and 13 more

Abstract read
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Strategic consensus on the clinical translation of advanced therapies in paediatric rare neurological disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  6. Article
  7. Neuroscience Needs Behavioral "Wind Tunnels" for Real-Life Translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Review
  10. Life-Course Brain Health as a Determinant of Late-Life Mental Health: American Association for Geriatric Psychiatry Expert Panel Recommendations.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Article
  11. The Latin American Brain Health Institute, a regional initiative to reduce the scale and impact of dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  12. Investing in Late-Life Brain Capital.Innovation in aging · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Harris A EyreOrganisation for Economic Co-operation and Development (OECD), Paris, France; The PRODEO Institute, San Francisco, CA, USA; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia; Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. Electronic address: harris@prodeobrain.com.
Rym AyadiEuro-Mediterranean Economists Association, Barcelona, Spain.
William EllsworthStanford University, Palo Alto, CA, USA.
Gowri AragamStanford University, Palo Alto, CA, USA.
Erin SmithOrganisation for Economic Co-operation and Development (OECD), Paris, France; The PRODEO Institute, San Francisco, CA, USA; Stanford University, Palo Alto, CA, USA.
Walter D DawsonDepartment of Neurology, School of Medicine, Oregon Health and Science University, Portland, OR, USA; Institute on Aging, College of Urban and Public Affairs, Portland State University, Portland, OR, USA; Global Brain Health Institute, University of California, San Francisco, CA, USA and Trinity College Dublin, Ireland.
Agustin IbanezGlobal Brain Health Institute, University of California, San Francisco, CA, USA and Trinity College Dublin, Ireland; Cognitive Neuroscience Center (CNC), Universidad San Andres, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Cara AltimusCenter for Strategic Philanthropy, Milken Institute, Washington, DC, USA.
Michael BerkIMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia; Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia; Orygen Youth Health, University of Melbourne, Melbourne, VIC, Australia; The Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Husseini K ManjiScience for Minds, Johnson & Johnson, Titusville, NJ, USA.
Eric A StorchDepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Marion LeboyerPsychiatry Department, University Paris Est Créteil, INSERM U955, FondaMental Foundation, Creteil, France.
Naoko KawaguchiOrganisation for Economic Co-operation and Development (OECD), Paris, France.
Michael FreemanDepartment of Psychiatry, University of California San Francisco School of Medicine, San Francisco, CA, USA.
Patrick BrannellyGates Ventures Alzheimer's Disease Data Initiative, Piedmont, CA, USA.
Facundo ManesNational Scientific and Technical Research Council (CONICET), Godoy Cruz 2290, Piso 9 (C1425FQB), Buenos Aires, Argentina; Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
Sandra B ChapmanCenter for BrainHealth, Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Jeffrey CummingsChambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, Las Vegas, NV, USA.
Carol GrahamBrookings Institution, Washington, DC, USA; School of Public Policy, University of Maryland, College Park, MD, USA; Gallup, Washington, DC, USA.
Benjamin F MillerWellbeing Trust, Washington, DC, USA; Department of Family Medicine at the University of Colorado School of Medicine, Denver, CO, USA.
Zoltan SarnyaiLaboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia.
Retsina MeyerDelix Therapeutics, Boston, MA, USA.
William HynesOrganisation for Economic Co-operation and Development (OECD), Paris, France.

Funding

Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's DiseaseR01AG053798 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AISEN, PAUL S., CUMMINGS, JEFFREY L. · 2017 to 2022
$39.4M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9M
Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI Robert J. Fox, Jefferson Kinney · 2015 to 2026
$22.8M
Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0M
NVEDARC Clinical CoreP20AG068053 · NIA · CLEVELAND CLINIC FOUNDATION · PI FOX, ROBERT J. · 2020 to 2022
$3.3M
Alzheimer's Clinical Trial InnOvatioN (ACTION) InitiativeR35AG071476 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI CUMMINGS, JEFFREY L. · 2021 to 2025
$2.9M
NIA NIH HHS P20 AG068053NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG053798NIA NIH HHS R35 AG071476NIGMS NIH HHS P20 GM109025NINDS NIH HHS U01 NS093334
6 · The paper itself

Abstract

Brains are indispensable drivers of human progress. Why not invest more heavily in them? We seek to place Brain Capital at the center of a new narrative to fuel economic and societal recovery and resilience.

Indexed as

BrainCapital FinancingHealth PromotionInterdisciplinary ResearchNeurosciencesBiomedical ResearchHumansInterdisciplinary Communication

Identifiers

PMID33957073
PMCPMC8240507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.