Evidence map›Paper›PMID 33957045›Full record

ArticleJournal of the American Chemical Society2021

AoiQ Catalyzes Geminal Dichlorination of 1,3-Diketone Natural Products.

Mengting Liu, Masao Ohashi, Yiu-Sun Hung, Kirstin Scherlach, Kenji Watanabe, Christian Hertweck, Yi Tang

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A fungal natural product that inhibits plant cellulose biosynthesis by disrupting cellulose synthase complexes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. In Vivo Characterization of theJournal of fungi (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Article
  8. Gunacins: Novel Benzo[ACS omega · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Unlocking the catalytic precision of ligand-controlled enzymatic halogenation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Enzymatic Halogenation of Terminal Alkynes.Journal of the American Chemical Society · 2023
    Article
  17. Article
  18. Review
  19. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengting LiuHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Yiu-Sun Hung
Kirstin ScherlachLeibniz Institute for Natural Product Research and Infection Biology - HKI, 07745 Jena, Germany.
Kenji WatanabeDepartment of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.ORCID 0000-0002-0463-4831
Christian HertweckLeibniz Institute for Natural Product Research and Infection Biology - HKI, 07745 Jena, Germany.

Funding

MIRA: Enzymology and Self-Resistance of Natural Product BiosynthesisR35GM118056 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yi Tang · 2016 to 2026
$6.1M
Time-of-Flight Mass Spectrometer for Synthesis Supporting Biomedical ResearchS10RR025631 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUK, KENDALL N · 2009 to 2009
$328k
NCRR NIH HHS S10 RR025631NIGMS NIH HHS R35 GM118056
6 · The paper itself

Abstract

Enzymes that can perform halogenation of aliphatic carbons are of significant interest to the synthetic and biocatalysis communities. Here we describe the characterization of AoiQ, a single-component flavin-dependent halogenase (FDH) that catalyzes

Indexed as

Biological ProductsFlavinsHalogenationKetonesMolecular ConformationOxidoreductasesBiological ProductsFlavinsKetonesOxidoreductases

Identifiers

PMID33957045
PMCPMC8434754

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.