Evidence map›Paper›PMID 33957040›Full record

ArticleJournal of the American Chemical Society2021

Detection of Water Molecules on the Radical Transfer Pathway of Ribonucleotide Reductase by

Fabian Hecker, JoAnne Stubbe, Marina Bennati

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Multiple quantumScience advances · 2026
    Article
  2. Low-barrier hydrogen bond powers long-range radical transfer in the metal-free ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Conformationally gated multisite proton-coupled electron transfer in the ribonucleotide reductaseProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Frequency and time domainPhysical chemistry chemical physics : PCCP · 2025
    Article
  7. 2.6-Å resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor NProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Angewandte Chemie (International ed. in English) · 2023
    Article
  14. Article
  15. Journal of the American Chemical Society · 2022
    Article
  16. Kinetic model for reversible radical transfer in ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Radicals in Biology: Your Life Is in Their Hands.Journal of the American Chemical Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Fabian HeckerMax Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
JoAnne StubbeDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 20139, United States.ORCID 0000-0001-8076-4489
Marina BennatiMax Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.ORCID 0000-0001-6784-7845
Max Planck Institute for Biophysical Chemistry · DEMassachusetts Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of water in biological proton-coupled electron transfer (PCET) is emerging as a key for understanding mechanistic details at atomic resolution. Here we demonstrate

Indexed as

Density Functional TheoryElectronsElectron Spin Resonance SpectroscopyElectron TransportEscherichia coliFree RadicalsOxygen IsotopesRibonucleotide ReductasesTyrosineWaterFree RadicalsOxygen-17Oxygen IsotopesRibonucleotide ReductasesTyrosineWater

Identifiers

PMID33957040
PMCPMC8154519
OpenAlexW3159106559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.