Evidence map›Paper›PMID 33956997›Full record

ArticlePaediatric and perinatal epidemiology2021

Birth outcomes affecting infants of mothers with intellectual and developmental disabilities.

Eric Rubenstein, Deborah B Ehrenthal, David C Mallinson, Lauren Bishop, Hsiang-Hui Kuo, Maureen S Durkin

Open access · greenAbstract read
In one paragraph

Article in Paediatric and perinatal epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eric RubensteinWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-9146-4497
Deborah B EhrenthalDepartment of Population Health Science, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
David C MallinsonDepartment of Population Health Science, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0003-1069-6040
Lauren BishopWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Hsiang-Hui KuoDepartment of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Maureen S DurkinWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin–Madison · USBoston University · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Institutional Career Development CoreKL2TR002374 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Bo Liu, Marin Leigh Schweizer · 2017 to 2026
$9.7M
Diversity supplementT32HD007014 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine J. Curtis · 1985 to 2026
$6.8M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
PREGNANCY RATES, RISK FACTORS, AND CHILD AND MOTHER OUTCOMES FOR WOMEN WITH INTELLECTUAL AND DEVELOPMENTAL DISABILITIES IN WISCONSIN.R03HD099619 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI RUBENSTEIN, ERIC S · 2019 to 2020
$160k
NCATS NIH HHS KL2 TR000428NCATS NIH HHS KL2 TR002374NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NICHD NIH HHS R03 HD099619NICHD NIH HHS T32 HD007014NICHD NIH HHS U54 HD090256
6 · The paper itself

Abstract

backgroundWomen with intellectual and developmental disabilities (IDD) face increased risk of adverse maternal pregnancy outcomes, yet less is known about infant outcomes.

objectivesTo examine birth outcomes of infants born to mothers with IDD and assess associations with demographics and IDD-type.

methodsWe used data from the Big Data for Little Kids project, which links Wisconsin birth records to Medicaid claims for live births covered by Medicaid from 2007 to 2016. We identified IDD using maternal prepregnancy Medicaid claims and ran Poisson regression (with a log link function) with robust variance clustered by mother to compare prevalence of outcomes between singleton births with and without mothers with IDD. We adjusted the associations for demographic factors and estimated prevalence ratios (PR) as the effect measure. We assessed outcomes by IDD-type (intellectual disability, genetic conditions, cerebral palsy, and autism spectrum disorder) to explore differences by categories of IDD.

resultsOf 267,395 infants, 1696 (0.6%) had mothers with IDD. A greater percentage of infants with mothers with IDD were born preterm (12.8% vs 7.8%; PR 1.64, 95% confidence interval [CI] 1.42, 1.89), small for gestational age (8.5% vs 5.4%; PR 1.42, 95% CI 1.25, 1.61), and died within 12 months of birth (3.2% vs 0.7%; PR 4.93, 95% CI 3.73, 6.43) compared to infants of mothers without IDD. Prevalence ratios were robust to adjustment for demographics factors. Estimates did not meaningfully differ when comparing different IDD-types.

conclusionsA greater porportion of infants born to mothers with IDD who were covered by Medicaid had poor outcomes compared to other infants. Prevalence of poor infant outcomes was greater for mothers with IDD even after accounting for demographic differences. It is imperative to understand why infants of mothers with IDD are at greater risk so interventions and management can be developed.

Indexed as

Autism Spectrum DisorderIntellectual DisabilityPremature BirthChildDevelopmental DisabilitiesFemaleHumansInfantInfant, NewbornMothersPregnancyPregnancy OutcomeUnited Stateshealth disparityintellectual and developmental disabilitiesMedicaidpreterm birthsize for gestational age

Identifiers

PMID33956997
PMCPMC8545714
OpenAlexW3158681556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.