ArticlePloS one2021
Integrating transcriptome and metabolome analyses of the response to cold stress in pumpkin (Cucurbita maxima).
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Dynamic transcriptomic and metabolomic adaptation mechanisms of Trifolium ambiguum under different durations of cold stress.Scientific reports · 2025Article
- Exogenous Sugar Alleviates Salt Stress in Cucumber Seedlings by Regulating the Antioxidant System and Hormone Signaling.Current issues in molecular biology · 2025Article
- Progress in Transcriptomics and Metabolomics in Plant Responses to Abiotic Stresses.Current issues in molecular biology · 2025Review
- Salt Stress Leads to Morphological and Transcriptional Changes in Roots of Pumpkins (Plants (Basel, Switzerland) · 2025Article
- Cold stress adaptation inFrontiers in plant science · 2025Article
- Enhanced HSP70 binding to mBMC plant biology · 2024Article
- A Multi-Omics View of Maize's (International journal of molecular sciences · 2024Article
- Integrative multi-omics analysis of chilling stress in pumpkin (Cucurbita moschata).BMC genomics · 2024Article
- Comparative transcriptomics analysis of tolerant and sensitive genotypes reveals genes involved in the response to cold stress in bitter gourd (Momordica charantia L.).Scientific reports · 2024Article
- Multi-Omics Approaches in Oil Palm Research: A Comprehensive Review of Metabolomics, Proteomics, and Transcriptomics Based on Low-Temperature Stress.International journal of molecular sciences · 2024Review
- Cold-stress induced metabolomic and transcriptomic changes in leaves of three mango varieties with different cold tolerance.BMC plant biology · 2024Article
- Integrated Transcriptomic and Metabolomics Analyses Reveal Molecular Responses to Cold Stress in Coconut (International journal of molecular sciences · 2023Article
- Integration of the metabolome and transcriptome reveals the molecular mechanism of drought tolerance inFrontiers in genetics · 2023Article
- Transcriptome and Physiological Analysis of Rootstock Types and Silicon Affecting Cold Tolerance of Cucumber Seedlings.Plants (Basel, Switzerland) · 2022Article
- Transcriptomic analysis unravels the molecular response ofFrontiers in plant science · 2022Article
- Transcriptomic Analysis Reveals Potential Gene Regulatory Networks Under Cold Stress of Loquat (Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cucurbita maxima belong to the genus Cucurbita and are of nutritional and economic importance. Physiological activity, transcriptome, and metabolome analyses of leaf samples from the C. maxima inbreding line IL7 treated at 5 °C and 25 °C were performed. Cold stress resulted in a significant increase in the malondialdehyde content, relative electrical conductivity, soluble protein, sugar content, and catalase activity. A total of 5,553 differentially expressed genes were identified, of which 2,871 were up-regulated and 2,682 down-regulated. In addition, the transcription of differentially expressed genes in the plant hormone signal transduction pathway and transcription factor families of AP2/ERF, bHLH, WRKY, MYB, and HSF was activated. Moreover, 114 differentially expressed metabolites were identified by gas chromatography time-of-flight mass spectrometry, particularly through the analysis of carboxylic acids and derivatives, and organooxygen compounds. The demonstration of a series of potential metabolites and corresponding genes highlighted a comprehensive regulatory mechanism. These findings will provide novel insights into the molecular mechanisms associated with the response to cold stress in C. maxima.
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