ArticleBiophysical journal1988
Capacitance measurements. An analysis of the phase detector technique used to study exocytosis and endocytosis.
Article in Biophysical journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Membrane capacitance measurements revisited: dependence of capacitance value on measurement method in nonisopotential neurons.Journal of neurophysiology · 2009Article
- Zf-and-Hsys-based Cm measurement under the whole-cell patch-clamp recording.Pflugers Archiv : European journal of physiology · 2009Article
- Measurements of membrane patch capacitance using a software-based lock-in system.Pflugers Archiv : European journal of physiology · 2007Article
- Neutrophil secretion induced by an intracellular Ca2+ rise and followed by whole-cell patch-clamp recordings occurs without any selective mobilization of different granule populations.Journal of biomedicine & biotechnology · 2006Article
- Kinetics of exocytosis is faster in cones than in rods.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Deletion of the synaptic protein interaction site of the N-type (CaV2.2) calcium channel inhibits secretion in mouse pheochromocytoma cells.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Determination of cell capacitance using the exact empirical solution of partial differential Y/partial differential Cm and its phase angle.Biophysical journal · 2004Article
- Ca(2+) and frequency dependence of exocytosis in isolated somata of magnocellular supraoptic neurones of the rat hypothalamus.The Journal of physiology · 2004Article
- Robust, high-resolution, whole cell patch-clamp capacitance measurements using square wave stimulation.Biophysical journal · 2001Article
- Resolution of patch capacitance recordings and of fusion pore conductances in small vesicles.Biophysical journal · 2000Article
- Tyrosine phosphorylation regulates rapid endocytosis in adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion.Molecular biology of the cell · 1999Article
- A current activated on depletion of intracellular Ca2+ stores can regulate exocytosis in adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Lambert-Eaton antibodies inhibit Ca2+ currents but paradoxically increase exocytosis during stimulus trains in bovine adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Diffusion barriers limit the effect of mobile calcium buffers on exocytosis of large dense cored vesicles.Biophysical journal · 1999Article
- Membrane capacitance changes associated with particle uptake during phagocytosis in macrophages.Biophysical journal · 1998Article
- Ca2+, annexins, and GTP modulate exocytosis from maize root cap protoplastsThe Plant cell · 1998Article
- Fusion pore conductance: experimental approaches and theoretical algorithms.Biophysical journal · 1998Article
- Barium triggers rapid endocytosis in calf adrenal chromaffin cells.The Journal of physiology · 1998Article
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Authors and funding
2 authors.
Funding
Abstract
We have studied the admittance of patch-clamped mast cells during exocytosis and found that they are adequately described by a four parameter equivalent circuit. On the basis of these measurements, we show that, contrary to current belief, when using a phase sensitive detector, small capacitance changes due to exocytosis or endocytosis should be studied by measuring current 90 degrees out of phase, relative to the component that corresponds to changes in series resistance. We have extended the theory on phase-detectors to include the errors in the estimation of step changes of membrane capacitance. We show that the measured capacitance of a secretory granule can be up to 80% smaller than its true value, during the course of a typical mast cell degranulation. We also describe a software-based phase-detector that simplifies capacitance measurements.
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