Evidence map›Paper›PMID 33956297›Full record

ReviewJournal of molecular neuroscience : MN2021

Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets.

Komal Thapa, Heena Khan, Thakur Gurjeet Singh, Amarjot Kaur

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 166 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06631547 phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Progesterone Administration on Severely Head Injured Patients: Hospital Based Study

TypeinterventionalSponsorAssiut UniversityRan2025 to 2027Enrolled50ConditionsSevere Head TraumaArmsProgesterone, The usual head trauma care
NCT07406555 phase4completednot on this mapstarted 2025, after this paper: background citation

Differences in C-Reactive Protein Levels Between Traumatic Brain Injury Patients Receiving Dexmedetomidine and Those Not Receiving Dexmedetomidine Undergoing Craniotomy at Prof. Dr. Margono Soekarjo Regional General Hospital, Purwokerto

TypeinterventionalSponsorUniversitas Jenderal SoedirmanRan2025 to 2025Enrolled25ConditionsTraumatic Brain InjuryArmsDexmedetomidine, Sufentanyl
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Pooled it
  7. Pooled it
  8. Trial
  9. Nitric oxide and traumatic brain injury.Medical gas research · 2027
    Review
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Komal ThapaChitkara College of Pharmacy, Chitkara University, Punjab, India.
Heena KhanChitkara College of Pharmacy, Chitkara University, Punjab, India.
Thakur Gurjeet SinghChitkara College of Pharmacy, Chitkara University, Punjab, India. gurjeet.singh@chitkara.edu.in.ORCID http://orcid.org/0000-0003-2979-1590
Amarjot KaurChitkara College of Pharmacy, Chitkara University, Punjab, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary injury mechanisms. Primary injury causes local brain damage, while secondary damage begins with inflammatory activity followed by disruption of the blood-brain barrier (BBB), peripheral blood cells infiltration, brain edema, and the discharge of numerous immune mediators including chemotactic factors and interleukins. TBI alters molecular signaling, cell structures, and functions. Besides tissue damage such as axonal damage, contusions, and hemorrhage, TBI in general interrupts brain physiology including cognition, decision-making, memory, attention, and speech capability. Regardless of the deep understanding of the pathophysiology of TBI, the underlying mechanisms still need to be assessed with a desired therapeutic agent to control the consequences of TBI. The current review gives a brief outline of the pathophysiological mechanism of TBI and various biochemical pathways involved in brain injury, pharmacological treatment approaches, and novel targets for therapy.

Indexed as

AnimalsBrain Injuries, TraumaticHumansNeuroprotective AgentsNF-kappa BOxidative StressSignal TransductionNeuroprotective AgentsNF-kappa BApoptosisExcitotoxicityMitochondrial dysfunctionNeuroinflammationNuclear factor-kappa B (NF-κB)Oxidative stressTraumatic brain injury

Identifiers

PMID33956297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.