Observational studyThe journal of spinal cord medicine2023
Prescribing patterns for treating common complications of spinal cord injury.
Observational study in The journal of spinal cord medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- The Effect of Antinociceptive Dose of Morphine on Cell Therapy in Rats with Spinal Cord Injury.Molecular neurobiology · 2025Article
- Role of gabapentin in the management of neurogenic overactive bladders: A systematic review.Central European journal of urology · 2025Review
- Article
- Potentially harmful drug-drug interactions in the therapeutic regimens of persons with spinal cord injury.The journal of spinal cord medicine · 2024Observational
- A scoping review on muscle cramps and spasms in upper motor neuron disorder-two sides of the same coin?Frontiers in neurology · 2024Article
- Article
- Prescribing for common complications of spinal cord injury.Canadian family physician Medecin de famille canadien · 2022Article
- Implications of Polypharmacy to Clinical Practice for Traumatic Spinal Cord Injury: A Population-Based Approach in British Columbia, Canada.Neurotrauma reportsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to find the most and least commonly prescribed medications for treating secondary health complications associated with spinal cord injury (SCI); and determine overall polypharmacy rates and risk factors associated with it.
designObservational design, cross-sectional analysis.
settingCommunity; Canada.
participantsIndividuals with spinal cord injury (
resultsA total of 515 prescriptions were issued to the sample comprising 213 different medications to treat 10 SCI-related complications. Forty-five (45%) participants were prescribed >5 medications concurrently. No associations were found between the number of drugs taken and age, sex, level of injury, completeness of injury, time since injury, or cause of injury. The most commonly treated complications included pain (56.5%), muscle spasms (54%) and urinary tract infections (43%). Anti-convulsants (pregabalin, gabapentin), anti-spasmodics (baclofen, diazepam) and nitrofurantoins (Macrobid) were the most commonly prescribed medications to treat each of the three conditions, respectively. Thirty five percent of the total sample received a combination of two or more analgesics including fourth-line agents in the opiate class (hydromorphone, hydrocodone and morphine). Similarly, some participants were prescribed general muscle relaxants and cephalosporins for treatment of muscle spasms and urinary tract infections, respectively, that are generally not recommended in SCI patients. We compare these prescribing patterns with the available clinical practice guidelines and highlight areas where the prescriptions fall outside the recommended clinical practice while considering the complexity of medication management in SCI.
conclusionMedication management in SCI is complex. Tools are required that enable prescribers to choose evidence-based medical regimens and deprescribe potentially inappropriate medications for their patients with SCI.
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