Evidence map›Paper›PMID 33955744›Full record

ArticleACS chemical biology2021

Synthase-Selective Exploration of a Tunicate Microbiome by Activity-Guided Single-Cell Genomics.

Woojoo E Kim, Katherine Charov, Mária Džunková, Eric D Becraft, Julia Brown, Frederik Schulz, Tanja Woyke, James J La Clair, Ramunas Stepanauskas, Michael D Burkart

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Woojoo E KimDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.
Katherine CharovDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.
Mária DžunkováDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Mail Stop: 91R183, 1 Cyclotron Road, Berkeley, California 94720, United States.
Eric D BecraftBigelow Laboratory for Ocean Sciences, East Boothbay, Maine 04544, United States.
Julia BrownBigelow Laboratory for Ocean Sciences, East Boothbay, Maine 04544, United States.
Frederik SchulzDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Mail Stop: 91R183, 1 Cyclotron Road, Berkeley, California 94720, United States.
Tanja WoykeDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Mail Stop: 91R183, 1 Cyclotron Road, Berkeley, California 94720, United States.
James J La ClairDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.
Ramunas StepanauskasBigelow Laboratory for Ocean Sciences, East Boothbay, Maine 04544, United States.
Michael D BurkartDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.ORCID 0000-0002-4472-2254
University of California San Diego · USLawrence Berkeley National Laboratory · USBigelow Laboratory for Ocean Sciences · USUniversity of North Alabama · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Protein-Protein Interactions in Natural Product BiosynthesisR01GM095970 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2012 to 2025
$5.9M
Single cell enzymatic discovery and antibiotic targetingR21AI134037 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D., STEPANAUSKAS, RAMUNAS · 2017 to 2018
$401k
NIAID NIH HHS R21 AI134037NIGMS NIH HHS R01 GM095970NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

While thousands of environmental metagenomes have been mined for the presence of novel biosynthetic gene clusters, such computational predictions do not provide evidence of their

Indexed as

AnimalsBacillus subtilisCarrier ProteinsCiona intestinalisComputational BiologyEscherichia coliFlow CytometryGenomicsMicrobiotaMultigene FamilyPeptide SynthasesPhylogenyPolyketidesSecondary MetabolismSiderophoresSingle-Cell AnalysisCarrier Proteinsnon-ribosomal peptide synthasePeptide SynthasesPolyketidesSiderophores

Identifiers

PMID33955744
PMCPMC9884146
OpenAlexW3159051595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.