ArticleImmunity, inflammation and disease2021
Expression of OPN3 in acral lentiginous melanoma and its associated with clinicohistopathologic features and prognosis.
Article in Immunity, inflammation and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma.Oncology research · 2025Article
- UVA Irradiation Promotes Melanoma Cell Proliferation Mediated by OPN3 Independently of ROS Production.Pigment cell & melanoma research · 2025Article
- Blue light-driven cell cycle arrest in thyroid cancer via Retinal-OPN3 complex.Cell communication and signaling : CCS · 2024Article
- Advances in prognostic models for osteosarcoma risk.Heliyon · 2024Review
- Expression Analysis of Retinal G Protein-coupled Receptor and its Correlation with Regulation of the Balance between Proliferation and Aberrant Differentiation in Cutaneous Squamous Cell Carcinoma.Acta dermato-venereologica · 2024Article
- Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation.Communications biology · 2023Article
- Total coumarins of Pileostegia tomentella induces cell death in SCLC by reprogramming metabolic patterns, possibly through attenuating β-catenin/AMPK/SIRT1.Chinese medicine · 2023Article
- Integrated analysis of the prognostic and oncogenic roles of OPN3 in human cancers.BMC cancer · 2022Article
- Prediction and Identification of GPCRs Targeting for Drug Repurposing in Osteosarcoma.Frontiers in oncology · 2022Article
- Expression of OPN3 in acral lentiginous melanoma and its associated with clinicohistopathologic features and prognosis.Immunity, inflammation and disease · 2021Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundOPN3 upregulation associated with metastasis was recently described in two subtypes of lung cancers. And OPN3 identified in light-independent functions in epidermal melanocytes has already shown promise. However, in malignant melanocytic tissues, the expression and characterization of OPN3 remain uncharacterized.
objectivesWe investigated the clinico-histopathologic features in relation to OPN3 expression of acral lentiginous melanoma (ALM), which is a rare cutaneous melanoma subtype and not associated with prior sunlight exposure.
methodsIn all, 84 samples of junctional melanocytic nevi (JMN, n = 12), primary ALMs (n = 39) and inguinal lymph node metastasis (ILNM, n = 23) from ALMs were evaluated for the immunohistochemical expression of OPN3. OPN3 messenger RNA and protein level were further determined in melanocytic tumors using quantitative real-time PCR, multiimmunofluorescence and Western blot assays. We also estimated the associations OPN3 expression between clinicopathological features and prognosis.
resultsILNMs, in contrast to JMN and ALMs, had higher OPN3 expression scores (p < .001) by immunohistochemistry analysis. High OPN3 score was associated with presence of ulceration, increased Breslow depth and Clark level (p = .025, p = .042, and p = .012, respectively). Furthermore, a remarkable difference (p = .037) of patient overall survival was found when comparing the OPN3 expression of immunohistochemical score between equal to or larger than 100 and below 100 groups. Also, Cox regression models showed that high OPN3 scores were associated with worse melanoma survival.
conclusionHigh OPN3 expression is significantly associated with ALMs and metastatic phenotype as well as a poor prognosis.
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