ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021
Expanding the Topological Landscape by a G-Column Flip of a Parallel G-Quadruplex.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Topological rules and anomalies in intramolecular G-quadruplex folding: a comprehensive study.Nucleic acids research · 2026Article
- Large-Scale Conformational Analysis Explains G-Quadruplex Topological Landscape.The journal of physical chemistry. B · 2025Article
- Comprehensive analysis of intramolecular G-quadruplex structures: furthering the understanding of their formalism.Nucleic acids research · 2024Article
- Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer.International journal of molecular sciences · 2023Article
- High-affinity binding at quadruplex-duplex junctions: rather the rule than the exception.Nucleic acids research · 2022Article
- Indoloquinoline Ligands Favor Intercalation at Quadruplex-Duplex Interfaces.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Expanding the Topological Landscape by a G-Column Flip of a Parallel G-Quadruplex.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Canonical G-quadruplexes can adopt a variety of different topologies depending on the arrangement of propeller, lateral, or diagonal loops connecting the four G-columns. A novel intramolecular G-quadruplex structure is derived through inversion of the last G-tract of a three-layered parallel fold, associated with the transition of a single propeller into a lateral loop. The resulting (3+1) hybrid fold features three syn⋅anti⋅anti⋅anti G-tetrads with a 3'-terminal all-syn G-column. Although the ability of forming a duplex stem-loop between G-tracts seems beneficial for a propeller-to-lateral loop rearrangement, unmodified G-rich sequences resist folding into the new (3+1) topology. However, refolding can be driven by the incorporation of syn-favoring guanosine analogues into positions of the fourth G-stretch. The presented hybrid-type G-quadruplex structure as determined by NMR spectroscopy may provide for an additional scaffold in quadruplex-based technologies.
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