Trial reportEuropean journal of clinical investigation2021
Effects of vegetarian versus Mediterranean diet on kidney function: Findings from the CARDIVEG study.
Trial report in European journal of clinical investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Effects of dietary interventions for metabolic acidosis in chronic kidney disease: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Pooled it
- The impact of a vegetarian diet on chronic kidney disease (CKD) progression - a systematic review.BMC nephrology · 2023Pooled it
- Effects of vegetarian versus Mediterranean diet on kidney function: Findings from the CARDIVEG study.European journal of clinical investigation · 2021Trial
- Longitudinal Assessment of Changes in Lifestyle Behaviors and Body Weight from Precollege to Adulthood.Nutrients · 2026Article
- Sex-Specific Biochemical and Histopathological Effects of Chronic Meat-Based vs. Plant-Based Burger Consumption in a Rodent Model.Foods (Basel, Switzerland) · 2025Article
- The 15-year trend in adherence to dietary recommendations and ultra-processed food consumption in Italy.Frontiers in nutrition · 2025Article
- New developments in epidemiological research on dietary patterns associated with chronic kidney disease.Frontiers in nutrition · 2025Review
- Association of blood urea nitrogen with all-cause and cardiovascular mortality in hyperlipidemia: NHANES 1999-2018.Lipids in health and disease · 2024Article
- Plant-based diets in patients with chronic kidney disease.Asian biomedicine : research, reviews and news · 2024Review
- Serum creatinine as an indicator of lean body mass in vegetarians and omnivores.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to assess the effects of a lacto-ovo-vegetarian diet (VD), compared to a Mediterranean diet (MD), on kidney function in a group of subjects with medium-to-low cardiovascular risk profile.
methodsWe analysed 107 subjects (82 women, 25 men; median age 52) who followed a VD (n = 54) and a MD (n = 53) for 3 months in the CARDIVEG study, a randomized, open, crossover trial that compared the effects of these 2 diets on cardiovascular disease risk.
resultsThe effect of the two diets on kidney function markers was evaluated by conducting a general linear model for repeated measurements adjusted for possible confounding factors such as age, sex, physical activity, alcohol, smoking, hypertension, LDL cholesterol, glucose and body weight change. A significant reduction in creatinine (-5.3%; P < .001), urea nitrogen levels (-9%; P = .001), blood urea nitrogen (BUN) (-8.7%; P = .001) and BUN/creatinine ratio (-5.8%; P < .001), and an increase in estimated glomerular filtration rate (eGFR) (+3.5%; P = .001) was observed during the VD period. On the contrary, no significant changes were noted in the MD group. Variations obtained in the two dietary interventions were significantly different (P < .0001) for creatinine levels, BUN/creatinine and eGFR, for which opposite trends were observed in the VD and MD groups.
conclusionsIn a selected group of subjects with medium-to-low cardiovascular risk profile, a 3 month VD period determined significant improvements in kidney function markers. Further trials are needed to confirm these results.
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