Evidence map›Paper›PMID 33955505›Full record

ArticleInternational journal of molecular medicine2021

Overexpression of microRNA‑486 affects the proliferation and chemosensitivity of mesothelioma cell lines by targeting

Silvana Pinelli, Rossella Alinovi, Diana Poli, Massimo Corradi, Giorgio Pelosi, Marcello Tiseo, Matteo Goldoni, Delia Cavallo, Paola Mozzoni

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Silvana PinelliDepartment of Medicine and Surgery, University of Parma, I-43126 Parma, Italy.
Rossella AlinoviDepartment of Medicine and Surgery, University of Parma, I-43126 Parma, Italy.
Diana PoliINAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Monte Porzio Catone, I-00078 Rome, Italy.
Massimo CorradiDepartment of Medicine and Surgery, University of Parma, I-43126 Parma, Italy.
Giorgio PelosiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, I-43124 Parma, Italy.
Marcello TiseoDepartment of Medicine and Surgery, University of Parma, I-43126 Parma, Italy.
Matteo GoldoniDepartment of Medicine and Surgery, University of Parma, I-43126 Parma, Italy.
Delia CavalloINAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Monte Porzio Catone, I-00078 Rome, Italy.
Paola MozzoniDepartment of Medicine and Surgery, University of Parma, I-43126 Parma, Italy.
University of Parma · ITIstituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulated levels of microRNAs (miRNAs or miRs), involved in oncogenic pathways, have been proposed to contribute to the aggressiveness of malignant pleural mesothelioma (MPM). Previous studies have highlighted the downregulation of miRNA miR‑486‑5p in patients with mesothelioma and the introduction of miRNA mimics to restore their reduced or absent functionality in cancer cells is considered an important therapeutic strategy. The aim of the present study was to evaluate the mechanisms through which miRNAs may influence the functions, proliferation and sensitivity to cisplatin of MPM cells. In the present study, a miR‑486‑5p mimic was transfected into the H2052 and H28 MPM cell lines, and cell viability, proliferation, apoptosis and mitochondrial membrane potential were monitored. miR‑486‑5p overexpression led to a clear impairment of cell proliferation, targeting

Indexed as

Gene Expression Regulation, NeoplasticAntineoplastic AgentsApoptosisCell Line, TumorCell ProliferationCisplatinHumansMesotheliomaMicroRNAsProto-Oncogene Proteins c-pim-1Up-RegulationAntineoplastic AgentsCisplatinMicroRNAsMIRN486 microRNA, humanPIM1 protein, humanProto-Oncogene Proteins c-pim-1CDK4cisplatin sensitivitymalignant pleural mesotheliomamiRNA‑486‑5pPIM1

Identifiers

PMID33955505
PMCPMC8083808
OpenAlexW3159767548

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.