ArticleThe Plant cell2021
The glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant immunity.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 145 citations in OpenAlex.
- Systemic acquired resistance: an emerging role for jasmonates in local signal biogenesis, translocation and distal signal decoding.The New phytologist · 2026Review
- LURP1, a SARD1-regulated protein, coordinates with the helper NLR ADR1 to promote plant immunity.The New phytologist · 2026Article
- Benzoic acid inhibits peach root growth and lateral root emergence by disrupting auxin homeostasis through salicylic acid accumulation.Plant cell reports · 2026Article
- Genome-wide identification and expression analysis of the UGT gene family in honeysuckle.BMC plant biology · 2026Article
- UGT76B1 and 41 Additional Arabidopsis UDP-Glycosyltransferases Show No Detectable In Vitro Glycosylation Activity TowardLife (Basel, Switzerland) · 2026Article
- Simultaneous Quantification of Salicylic Acid, Pipecolic Acid, and N-Hydroxypipecolic Acid in Plants Using High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Genome-wide identification and expression analysis of the PtrUGT gene family in Populus trichocarpa.BMC plant biology · 2025Article
- N-hydroxy-pipecolic acid-mediated signal transduction and resistance requires DAWDLE.Plant physiology · 2025Article
- The Pea Inner Nuclear Membrane SUN Domain Protein Modulates Plant (a)biotic Stress Responses by Regulating Nuclear Dynamics.Molecular plant pathology · 2025Article
- A root-based N-hydroxypipecolic acid standby circuit to direct immunity and growth of Arabidopsis shoots.Nature plants · 2025Article
- UDP-glycosyltransferase PpUGT74F2 is involved in fruit immunity via modulating salicylic acid metabolism.Horticulture research · 2025Article
- Multi-omics analysis identified the GmUGT88A1 gene, which coordinately regulates soybean resistance to cyst nematode and isoflavone content.Plant biotechnology journal · 2025Article
- Salicylic acid: The roles in plant immunity and crosstalk with other hormones.Journal of integrative plant biology · 2025Review
- The branched-chain amino acid-related isoleucic acid: recent research advances.Plant biology (Stuttgart, Germany) · 2025Review
- Evolution and functional divergence of glycosyltransferase genes shaped the quality and cold tolerance of tea plants.The Plant cell · 2024Article
- Transcriptome analysis reveals role of transcription factor WRKY70 in early N-hydroxy-pipecolic acid signaling.Plant physiology · 2024Article
- Phosphoproteomic analysis uncovers phosphorylated proteins in response to salicylic acid and N-hydroxypipecolic acid in Arabidopsis.Molecular biology reports · 2024Article
- The Induction of Disease Resistance by Scopolamine and the Application ofInternational journal of molecular sciences · 2024Article
- Use of CRISPR Technology in Gene Editing for Tolerance to Biotic Factors in Plants: A Systematic Review.Current issues in molecular biology · 2024Review
- HScience (New York, N.Y.) · 2024Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tradeoff between growth and defense is a critical aspect of plant immunity. Therefore, the plant immune response needs to be tightly regulated. Salicylic acid (SA) is an important plant hormone regulating defense against biotrophic pathogens. Recently, N-hydroxy-pipecolic acid (NHP) was identified as another regulator for plant innate immunity and systemic acquired resistance (SAR). Although the biosynthetic pathway leading to NHP formation is already been identified, how NHP is further metabolized is unclear. Here, we present UGT76B1 as a uridine diphosphate-dependent glycosyltransferase (UGT) that modifies NHP by catalyzing the formation of 1-O-glucosyl-pipecolic acid in Arabidopsis thaliana. Analysis of T-DNA and clustered regularly interspaced short palindromic repeats (CRISPR) knock-out mutant lines of UGT76B1 by targeted and nontargeted ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) underlined NHP and SA as endogenous substrates of this enzyme in response to Pseudomonas infection and UV treatment. ugt76b1 mutant plants have a dwarf phenotype and constitutive defense response which can be suppressed by loss of function of the NHP biosynthetic enzyme FLAVIN-DEPENDENT MONOOXYGENASE 1 (FMO1). This suggests that elevated accumulation of NHP contributes to the enhanced disease resistance in ugt76b1. Externally applied NHP can move to distal tissue in ugt76b1 mutant plants. Although glycosylation is not required for the long-distance movement of NHP during SAR, it is crucial to balance growth and defense.
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