ArticleThe Plant cell2021
The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 116 citations in OpenAlex.
- 3-dehydroquinate synthase contributes to anthocyanin accumulation and flower pigmentation in petunia.Protoplasma · 2026Article
- Chorismate and isochorismate turnover reveal hidden dynamics of aromatic metabolism in Arabidopsis leaves.The Plant cell · 2026Article
- Metabolic Rewiring of the Shikimate Pathway Enables Rose-Scented Rice.Plant biotechnology journal · 2026Article
- Compositional Variability of Rowanberry Genotypes and Sugar-Organic Acid Distribution Between Juice and Pomace.Molecules (Basel, Switzerland) · 2026Article
- Biostimulatory Effect of 3-Acetonyl-3-Hydroxyoxindole on the Growth and Secondary Metabolites ofInternational journal of molecular sciences · 2026Article
- Unveiling Dynamic Defense Pathways: Transcriptome Analysis of Phenylpropanoids and (Iso)flavonoids in Cowpea Leaves Post-CABMV Inoculation.Biochemical genetics · 2026Article
- Disruption of SlCNGC18 enhances Cucumber mosaic virus resistance and drought tolerance in tomato (Solanum lycopersicum L. cv. Micro-Tom).BMC plant biology · 2026Article
- Enhancement of Polysaccharides inJournal of fungi (Basel, Switzerland) · 2026Article
- Chassis selection and metabolic fine-tuning enable efficient in planta betalain production.Plant physiology · 2026Article
- Synergistic fungal consortia enhance maize growth and soil biological functions under microplastic stress.BMC plant biology · 2026Article
- Advances in the Application of Amino Acids in the Preservation of Postharvest Fruits and Vegetables.Foods (Basel, Switzerland) · 2026Review
- Prime editing of an RR26-responsive cis-element enhances DAHPS2 expression and submergence tolerance in rice through the shikimate pathway.Plant communications · 2026Article
- Integrated metabolomic, proteomic, and transcriptomic analyses reveal the production of bioactive metabolites and antidiabetic effects in matureFrontiers in plant science · 2026Article
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- Integrated proteomic and transcriptomic analyses of Citrus australasica in response to Candidatus Liberibacter asiaticus infection.BMC plant biology · 2025Article
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- Unravelling herbicide stress and its impact on metabolite profiling in Cannabis sativa: an investigative study.Journal of cannabis research · 2025Article
- Exogenous Melatonin Application Enhances Pepper (Foods (Basel, Switzerland) · 2025Article
- Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory.Biotech (Basel (Switzerland)) · 2025Review
- Phosphoenolpyruvate and Related Metabolic Pathways Contribute to the Regulation of Plant Growth and Development.International journal of molecular sciences · 2025Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant shikimate pathway directs bulk carbon flow toward biosynthesis of aromatic amino acids (AAAs, i.e. tyrosine, phenylalanine, and tryptophan) and numerous aromatic phytochemicals. The microbial shikimate pathway is feedback inhibited by AAAs at the first enzyme, 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DHS). However, AAAs generally do not inhibit DHS activities from plant extracts and how plants regulate the shikimate pathway remains elusive. Here, we characterized recombinant Arabidopsis thaliana DHSs (AthDHSs) and found that tyrosine and tryptophan inhibit AthDHS2, but not AthDHS1 or AthDHS3. Mixing AthDHS2 with AthDHS1 or 3 attenuated its inhibition. The AAA and phenylpropanoid pathway intermediates chorismate and caffeate, respectively, strongly inhibited all AthDHSs, while the arogenate intermediate counteracted the AthDHS1 or 3 inhibition by chorismate. AAAs inhibited DHS activity in young seedlings, where AthDHS2 is highly expressed, but not in mature leaves, where AthDHS1 is predominantly expressed. Arabidopsis dhs1 and dhs3 knockout mutants were hypersensitive to tyrosine and tryptophan, respectively, while dhs2 was resistant to tyrosine-mediated growth inhibition. dhs1 and dhs3 also had reduced anthocyanin accumulation under high light stress. These findings reveal the highly complex regulation of the entry reaction of the plant shikimate pathway and lay the foundation for efforts to control the production of AAAs and diverse aromatic natural products in plants.
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