Evidence map›Paper›PMID 33955207›Full record

ReviewESC heart failure2021

Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications.

Agata Bikiewicz, Maciej Banach, Stephan von Haehling, Marek Maciejewski, Agata Bielecka-Dabrowa

Registry-linked trialAbstract readReview
In one paragraph

Review in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05882578 (Effects of Exercise Oncology Intervention in Fitness Capacity and Body Composition in Breast Cancer Survivals), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05882578 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Exercise Oncology Intervention in Fitness Capacity and Body Composition in Breast Cancer Survivals

TypeinterventionalSponsorTigers Running ClubRan2023 to 2023Enrolled74ConditionsBreast Cancer, Cancer SurvivorsArmsOncological physical exercise intervention, Active Physical Activities intervention
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  20. Natural Taxanes: From Plant Composition to Human Pharmacology and Toxicity.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Agata BikiewiczHeart Failure Unit, Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Rzgowska 281/289, Lodz, 93-338, Poland.
Maciej BanachHeart Failure Unit, Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Rzgowska 281/289, Lodz, 93-338, Poland.
Stephan von HaehlingDepartment of Cardiology and Pneumology and German Center for Cardiovascular Research (DZHK), partner site Göttingen, University Medical Center Göttingen (UMG), Göttingen, Germany.
Marek MaciejewskiDepartment of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
Agata Bielecka-DabrowaHeart Failure Unit, Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Rzgowska 281/289, Lodz, 93-338, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most common cancer diagnosis in female population is breast cancer, which affects every year about 2.0 million women worldwide. In recent years, significant progress has been made in oncological therapy, in systemic treatment, and in radiotherapy of breast cancer. Unfortunately, the improvement in the effectiveness of oncological treatment and prolonging patients' life span is associated with more frequent occurrence of organ complications, which are side effects of this treatment. Current recommendations suggest a periodic monitoring of the cardiovascular system in course of oncological treatment. The monitoring includes the assessment of occurrence of risk factors for cardiovascular diseases in combination with the evaluation of the left ventricular systolic function using echocardiography and electrocardiography as well as with the analysis of the concentration of cardiac biomarkers. The aim of this review was critical assessment of the breast cancer therapy cardiotoxicity and the analysis of methods its detections. The new cardio-specific biomarkers in serum, the development of modern imaging techniques (Global Longitudinal Strain and Three-Dimensional Left Ventricular Ejection Fraction) and genotyping, and especially their combined use, may become a useful tool for identifying patients at risk of developing cardiotoxicity, who require further cardiovascular monitoring or cardioprotective therapy.

Indexed as

Breast NeoplasmsHeart DiseasesCardiotoxicityFemaleHumansStroke VolumeVentricular Function, LeftBiomarkersBreast cancerCardiotoxicityHeart failureOncological treatment

Identifiers

PMID33955207
PMCPMC8318493

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.