Evidence map›Paper›PMID 33955167›Full record

ArticlePediatric blood & cancer2021

How we approach thrombosis risk in children with COVID-19 infection and MIS-C.

Anjali A Sharathkumar, E Vincent S Faustino, Clifford M Takemoto

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Pediatric blood & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Treatment of multisystem inflammatory syndrome in children.World journal of pediatrics : WJP · 2024
    Review
  5. Review
  6. Review
  7. An extremely rare cause of flank pain: Answers.Pediatric nephrology (Berlin, Germany) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Thromboprophylaxis for children hospitalized with COVID-19 and MIS-C.Research and practice in thrombosis and haemostasis · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Treatment of MIS-C in Children and Adolescents.Current pediatrics reports · 2022
    Review
  16. Article
  17. The Trilogy of SARS-CoV-2 in Pediatrics (Part 3): Thrombosis, Anticoagulant, and Antiplatelet Considerations.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Anjali A SharathkumarStead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0003-4574-6175
E Vincent S FaustinoSection of Pediatric Critical Care Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.
Clifford M TakemotoDivision of Clinical Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
St. Jude Children's Research Hospital · USUniversity of Iowa · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Thrombosis within the microvasculature and medium to large vessels is a serious and common complication among critically ill individuals with coronavirus disease 2019 (COVID-19). While children are markedly less likely to develop severe disease than adults, they remain at risk for thrombosis during acute infection and with the post-acute inflammatory illness termed multisystem inflammatory syndrome in children. Significant knowledge deficits in understanding COVID-19-associated coagulopathy and thrombotic risk pose clinical challenges for pediatric providers who must incorporate expert opinion and personal experience to manage individual patients. We discuss clinical scenarios to provide framework for characterizing thrombosis risk and thromboprophylaxis in children with COVID-19.

Indexed as

COVID-19COVID-19 Drug TreatmentSystemic Inflammatory Response SyndromeThrombosisAdolescentAnticoagulantsChildFemaleHumansMaleSARS-CoV-2AnticoagulantsanticoagulationCOVID-19MIS-Cthrombosis

Identifiers

PMID33955167
PMCPMC8206673
OpenAlexW3158347572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.