SynthesisHuman brain mapping2021
Abnormal prediction error processing in schizophrenia and depression.
Synthesis in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Neurofunctional representations of instrumental learning in psychosis: a meta-analysis of neuroimaging studies.Psychological medicine · 2025Pooled it
- A meta-analysis of the neural substrates of monetary reward anticipation and outcome in alcohol use disorder.Human brain mapping · 2023Pooled it
- Abnormal prediction error processing in schizophrenia and depression.Human brain mapping · 2021Pooled it
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- Anticipatory pleasure as a key hedonic component in classifying major depressive disorder: multidimensional behavioral evidence from majority vote algorithm.BMC psychiatry · 2026Article
- Functional bipartition of medial prefrontal cortex into salience detection and movement gain.bioRxiv : the preprint server for biology · 2026Article
- Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2025Article
- Leveraging stacked classifiers for exploring the role of hedonic processing between major depressive disorder and schizophrenia.Psychological medicine · 2025Article
- Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.Psychological medicine · 2025Article
- Aberrant preparation of hand movement in schizophrenia spectrum disorder: an fMRI study.Brain communications · 2025Article
- Do people know how suicidal they will be? Understanding suicidal prospection.Suicide & life-threatening behavior · 2024Article
- Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task.Psychological medicine · 2023Article
- Reinforcement learning deficits exhibited by postnatal PCP-treated rats enable deep neural network classification.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Insular and Striatal Correlates of Uncertain Risky Reward Pursuit in Schizophrenia.Schizophrenia bulletin · 2023Article
- Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023Review
- Tactile suppression stems from specific sensorimotor predictions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A Predictive Coding Framework for Understanding Major Depression.Frontiers in human neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To make adaptive decisions under uncertainty, individuals need to actively monitor the discrepancy between expected outcomes and actual outcomes, known as prediction errors. Reward-based learning deficits have been shown in both depression and schizophrenia patients. For this study, we compiled studies that investigated prediction error processing in depression and schizophrenia patients and performed a series of meta-analyses. In both groups, positive t-maps of prediction error tend to yield striatum activity across studies. The analysis of negative t-maps of prediction error revealed two large clusters within the right superior and inferior frontal lobes in schizophrenia and the medial prefrontal cortex and bilateral insula in depression. The concordant posterior cingulate activity was observed in both patient groups, more prominent in the depression group and absent in the healthy control group. These findings suggest a possible role in dopamine-rich areas associated with the encoding of prediction errors in depression and schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.