Trial reportHuman brain mapping2021
Increased segregation of structural brain networks underpins enhanced broad cognitive abilities of cognitive training.
Trial report in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial.European stroke journal · 2026Trial
- The Effects of Computerized Cognitive Training in Older Adults' Cognitive Performance and Biomarkers of Structural Brain Aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Trial
- Effects of computerized cognitive training on structure‒function coupling and topology of multiple brain networks in people with mild cognitive impairment: a randomized controlled trial.Alzheimer's research & therapy · 2023Trial
- Increased segregation of structural brain networks underpins enhanced broad cognitive abilities of cognitive training.Human brain mapping · 2021Trial
- Predicting individual differences in digital alcohol intervention effectiveness through multimodal data.NPJ digital medicine · 2026Article
- Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial.European stroke journal · 2025Article
- Mechanisms of interventions targeting modifiable factors for dementia risk reduction.Molecular neurodegeneration · 2025Review
- Profiles of brain topology for dual-functional stability in old age.GeroScience · 2025Article
- Challenging Cognitive Load Theory: The Role of Educational Neuroscience and Artificial Intelligence in Redefining Learning Efficacy.Brain sciences · 2025Review
- Intrinsic functional connectivity brain networks mediate effect of age on sociability.PloS one · 2025Article
- Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study.The journal of headache and pain · 2024Article
- Brain network correlates of affective symptoms in aMCI.Aging brain · 2024Article
- Unifying framework for cognitive training interventions in brain aging.Ageing research reviews · 2022Review
- Methodological evaluation of individual cognitive prediction based on the brain white matter structural connectome.Human brain mapping · 2022Article
- Enhancing cortical network-level participation coefficient as a potential mechanism for transfer in cognitive training in aMCI.NeuroImage · 2022Article
- Asymptomatic carotid stenosis is associated with both edge and network reconfigurations identified by single-subject cortical thickness networks.Frontiers in aging neuroscience · 2022Article
- Computer Programming E-Learners' Personality Traits, Self-Reported Cognitive Abilities, and Learning Motivating Factors.Brain sciences · 2021Article
- Improving comparability across cognitive training trials for brain aging: A focus on interoperability.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A major challenge in the cognitive training field is inducing broad, far-transfer training effects. Thus far, little is known about the neural mechanisms underlying broad training effects. Here, we tested a set of competitive hypotheses regarding the role of brain integration versus segregation underlying the broad training effect. We retrospectively analyzed data from a randomized controlled trial comparing neurocognitive effects of vision-based speed of processing training (VSOP) and an active control consisting of mental leisure activities (MLA) in older adults with MCI. We classified a subset of participants in the VSOP as learners, who showed improvement in executive function and episodic memory. The other participants in the VSOP (i.e., VSOP non-learners) and a subset of participants in the MLA (i.e., MLA non-learners) served as controls. Structural brain networks were constructed from diffusion tensor imaging. Clustering coefficients (CCs) and characteristic path lengths were computed as measures of segregation and integration, respectively. Learners showed significantly greater global CCs after intervention than controls. Nodal CCs were selectively enhanced in cingulate cortex, parietal regions, striatum, and thalamus. Among VSOP learners, those with more severe baseline neurodegeneration had greater improvement in segregation after training. Our findings suggest broad training effects are related to enhanced segregation in selective brain networks, providing insight into cognitive training related neuroplasticity.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.