Evidence map›Paper›PMID 33955033›Full record

ArticleVeterinary surgery : VS2021

Biomechanical effects of a titanium intervertebral cage as a stand-alone device, and in combination with locking plates in the canine caudal cervical spine.

Rick Beishuizen, Tjarda E Reints Bok, Michelle Teunissen, Albert J van der Veen, Kaj S Emanuel, Marianna A Tryfonidou, Bjorn P Meij

Open access · hybridAbstract read
In one paragraph

Article in Veterinary surgery : VS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Comparison of osseointegration in 3D-printed hexanium titanium cages and PEEK cervical cages: In-vivo ovine cervical fusion model.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Rick BeishuizenDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Tjarda E Reints BokDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Michelle TeunissenDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Albert J van der VeenDepartment of Orthopedic Surgery, Amsterdam UMC, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Kaj S EmanuelDepartment of Orthopedic Surgery, Amsterdam UMC, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Marianna A TryfonidouDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Bjorn P MeijDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
University of Applied Sciences Utrecht · NLAmsterdam Neuroscience · NLAmsterdam University Medical Centers · NLUtrecht University · NL

Funding

Dutch Arthritis Society LLP22
6 · The paper itself

Abstract

objectiveTo evaluate the change in ex vivo biomechanical properties of the canine cervical spine, due to an intervertebral cage, both as a stand-alone device and in combination with plates. STUDY

designExperimental ex vivo study. ANIMALS: Cervical spinal segments (C5-C7) from eight canine cadavers.

methodsThe range of motion (ROM) and elastic zone stiffness (EZS) of the spines were determined with a four-point bending device in flexion/extension, lateral bending, and axial rotation for four conditions: native, discectomy, cage (at C6-C7), and cage with plates (at C6-C7). The disc height index (DHI) for each condition was determined using radiography.

resultsDiscectomy resulted in overall increased ROM (p < .01) and EZS (p < .05) and decreased DHI (p < .005) when compared to the native condition. Placement of the cage increased DHI (p < .001) and restored total ROM during flexion/extension, lateral bending and axial rotation, and EZS during flexion/extension to the level of the native spine. Application of the plates further reduced the total ROM during flexion/extension (p < .001) and lateral bending (p < .001), but restored ROM in extension and EZS during lateral bending. No implant failure, subsidence, or significant cage migration occurred during loading.

conclusionAn anchorless intervertebral cage used as a stand-alone device was able to restore the disc height and spinal stability to the level of the native cervical spine, whereas the addition of plates further reduced the spinal unit mobility. CLINICAL SIGNIFICANCE: This study implies that the intervertebral cage may be used as a stand-alone device in the spinal unit fixation in the canine cervical spine.

Indexed as

Biomechanical PhenomenaAnimalsBone PlatesBone ScrewsCadaverCervical VertebraeDiskectomyDog DiseasesDogsInternal FixatorsMusculoskeletal DiseasesOrthopedic ProceduresRadiographyRange of Motion, ArticularSpinal Cord DiseasesSpinal FusionTitanium

Identifiers

PMID33955033
PMCPMC8360106
OpenAlexW3159427933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.