Trial reportIntensive care medicine2021
Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia.
Trial report in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 6 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Pooled it
- Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026.Intensive care medicine · 2026Pooled it
- Design and maintenance of medical oxygen concentrators in Sub-Saharan Africa: a systematic review.BMC health services research · 2025Pooled it
- High flow nasal cannula for respiratory support in term infants.The Cochrane database of systematic reviews · 2023Pooled it
- Oxygen systems strengthening as an intervention to prevent childhood deaths due to pneumonia in low-resource settings: systematic review, meta-analysis and cost-effectiveness.BMJ global health · 2021Pooled it
- Non-Invasive Ventilation Strategies in Children With Acute Lower Respiratory Infection: A Systematic Review and Bayesian Network Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Conservative versus conventional oxygenation target in children admitted in PICU: a randomized controlled trial.European journal of pediatrics · 2026Trial
- Conservative versus liberal oxygenation targets in critically ill children: the Oxy-PICU RCT.Health technology assessment (Winchester, England) · 2026Trial
- Early weaning from oxygen therapy in African children with severe pneumonia.BMC medicine · 2025Trial
- Use of days alive without life support and similar count outcomes in randomised clinical trials - an overview and comparison of methodological choices and analysis methods.BMC medical research methodology · 2023Trial
- Management of Sepsis and Septic Shock in Children: Surviving Sepsis Campaign International Guidelines 2026.Indian pediatrics · 2026Review
- Medical oxygen and respiratory support requirements for patients hospitalised with COVID-19 in 23 low-income and middle-income countries: a prospective, observational cohort study.The Lancet. Global health · 2026Observational
- Risk factors for mortality in children with hypoxemia in resource-constrained settings: a secondary analysis of Global Paediatric Acute Critical Illness Point Prevalence Study (PARITY).BMC global and public health · 2026Article
- A cost-consequence analysis of the children's administration oxygenation strategies trial (COAST) in severe pneumonia.PLOS global public health · 2026Article
- Supportive care and in-hospital mortality among children with suspected sepsis in Bamako, Mali.Frontiers in pediatrics · 2026Article
- Advanced non-invasive respiratory support in resource-constrained settings: a narrative review.Critical care (London, England) · 2025Review
- Non-invasive respiratory support in pediatric patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis of randomized controlled trials.EClinicalMedicine · 2025Article
- Characteristics and outcomes of children initiated on high flow nasal cannula and continuous positive airway pressure at the emergency centre of a district hospital in South Africa.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2025Article
- Epidemiological dynamics of influenza B virus across multiple seasons in Kenya and Uganda inferred from sequence data, 2010-2021.BMC infectious diseases · 2025Article
- Review
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 4 countries.
Funding
Abstract
purposeThe life-saving role of oxygen therapy in African children with severe pneumonia is not yet established.
methodsThe open-label fractional-factorial COAST trial randomised eligible Ugandan and Kenyan children aged > 28 days with severe pneumonia and severe hypoxaemia stratum (SpO
resultsThe trial was stopped early after enrolling 1852/4200 children, including 388 in the severe hypoxaemia stratum (median 7 months; median SpO
conclusionsRespiratory support with HFNT showing potential benefit should prompt further trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.