Evidence map›Paper›PMID 33954827›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

The relationship between COVID-19's severity and ischemic stroke: a systematic review and meta-analysis.

Yue Lu, Jie-Ji Zhao, Meng-Fan Ye, Hong-Mei Li, Fei-Rong Yao, Yan Kong, Zhuan Xu

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Is a high chest CT severity score a risk factor for an increased incidence of long-term neuroimaging findings after COVID-19?Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yue Lu *Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jie-Ji Zhao *Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Meng-Fan YeDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Hong-Mei LiDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Fei-Rong YaoDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China. 67898526@163.com.
Yan KongDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China. kong0919@163.com.
Zhuan XuDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China. xuzhuan772@126.com.ORCID http://orcid.org/0000-0002-7745-9827
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aim to determine the risk of acute ischemic stroke in patients with severe and non-severe coronavirus disease 2019 (COVID-19).

methodsA literature search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases until October 28, 2020. Studies covering COVID-19's severity classification data and COVID-19 patients with acute ischemic stroke were included. Two independent evaluators extracted data, and the random effects model was used to calculate the risk ratios (RR) and 95% confidence interval (95% CI) of acute ischemic stroke associated with COVID-19's severity.

resultsA total of 8 studies were included, involving 5266 patients. Among all COVID-19 patients, the total incidence of ischemic stroke was 1.76% (95% CI: 0.82-3.01). Severe patients have an increased risk of acute ischemic stroke compared with non-severe patients (RR = 3.53, 95% CI: 2.06-6.07, P < 0.0001; I

conclusionsThis meta-analysis shows that the severe course of COVID-19 is associated with an increased risk of acute ischemic stroke.

Indexed as

Brain IschemiaCOVID-19Ischemic StrokeStrokeHumansSARS-CoV-2COVID-19Ischemic strokeMeta-analysisSeverity

Identifiers

PMID33954827
PMCPMC8098783
OpenAlexW3113308466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.