ArticlePediatric nephrology (Berlin, Germany)2021
Outcomes of solitary functioning kidneys-renal agenesis is different than multicystic dysplastic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Clinical course of unilateral multicystic dysplastic kidney and contralateral kidney in Korean children: a single-center, retrospective study.Childhood kidney diseases · 2026Article
- Unilateral Renal Agenesis: Prenatal Diagnosis and Postnatal Issues.Diagnostics (Basel, Switzerland) · 2025Review
- Clinical outcomes and risk factors in pediatric patients with solitary functioning kidney: a comparative analysis of congenital and acquired etiologies.Frontiers in pediatrics · 2025Article
- Early diagnosis of solitary functioning kidney: comparing the prognosis of kidney agenesis and multicystic dysplastic kidney.Pediatric nephrology (Berlin, Germany) · 2024Article
- Müllerian anomalies in girls with congenital solitary kidney.Pediatric nephrology (Berlin, Germany) · 2024Article
- Hypertension in children with congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2024Article
- Congenital anomalies of the kidney and urinary tract: defining risk factors of disease progression and determinants of outcomes.Pediatric nephrology (Berlin, Germany) · 2023Review
- Predicting outcomes in children with congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2023Article
- Early Renal Ultrasound in Patients with Congenital Solitary Kidney Can Guide Follow-Up Strategy Reducing Costs While Keeping Long-Term Prognostic Information.Journal of clinical medicine · 2022Article
- Risk stratification for children with a solitary functioning kidney.Pediatric nephrology (Berlin, Germany) · 2021Article
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8 authors at 1 institution in 1 country.
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Abstract
backgroundMulticystic dysplastic kidney (MCDK) disease and unilateral renal agenesis (URA) are well-known causes of a solitary functioning kidney (SFK) and are associated with long-term kidney injury. The aims of this study were to characterize the natural history of SFK at our center, define the risk factors associated with chronic kidney injury, and identify distinguishing features between URA and MCDK that predict outcome.
methodsThis was a retrospective cohort study of 230 SFK patients. We compared MCDK (n=160) and URA (n=70) according to clinical features at diagnosis and kidney outcomes over follow-up. Univariate and multivariate binary regression analysis was used to determine independent risk factors for chronic kidney injury, defined as the composite outcome of hypertension, proteinuria, or chronic kidney disease (eGFR <60 mL/min/1.73m
resultsURA had a higher prevalence of comorbid genetic syndromes (15 vs. 6%, p=0.04), non-renal anomalies (39 vs. 11%, p<0.001), and congenital anomalies of the kidney and urinary tract (CAKUT) (51 vs. 26%, p<0.001) than MCDK. Over follow-up, URA experienced more hypertension (19 vs. 3%, p=0.002), proteinuria (12 vs. 3%, p=0.03), and the composite outcome (19 vs. 6%, p=0.003) than MCDK. Independent risk factors for chronic kidney injury included CAKUT (OR 5.01, p=0.002) and URA (OR 2.71, p=0.04).
conclusionsIn our population, URA was more likely to have associated syndromes or anomalies, and to have worse outcomes over time than MCDK. URA diagnosis was an independent risk factor for chronic kidney injury. Our results will be used to develop a standardized clinical pathway for SFK management. A higher resolution version of the Graphical abstract is available as Supplementary information.
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