Evidence map›Paper›PMID 33954199›Full record

ArticleBioMed research international2021

Molecular Mechanism of 73HOXC-AS1-Activated Wnt

Shumin Zhang, Lianzhen Wang, Yuting Gao, Yanxia Fan, Gang Zhang, Yujie Zhang

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. There and Back Again: Hox Clusters Use Both DNA Strands.Journal of developmental biology · 2021
    Review
4 · The record

Corrections and comments

  • Retraction · 2024-01-09Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Peer Review · Investigation by Journal/Publisher · Investigation by Third Party · Paper Mill · Computer-Aided Content or Computer-Generated Content · Unreliable Results and/or Conclusions ·
  • Retracted
5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shumin ZhangDepartment of Gastroenterology, The Fourth People's Hospital of Jinan, Jinan 250031, China.
Lianzhen WangGastrointestinal Surgery, The Fourth People's Hospital of Jinan, Jinan 250031, China.
Yuting GaoDepartment of Nursing, The Fourth People's Hospital of Jinan, Jinan 250031, China.
Yanxia FanDepartment of Neurology, The Fourth People's Hospital of Jinan, Jinan 250031, China.
Gang ZhangDepartment of General Surgery, The Fourth People's Hospital of Jinan, Jinan 250031, China.ORCID https://orcid.org/0000-0002-8480-3710
Yujie ZhangDepartment of Nursing, The Fourth People's Hospital of Jinan, Jinan 250031, China.ORCID https://orcid.org/0000-0001-9108-9394
The Fourth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study is aimed at exploring the regulatory mechanism of 73HOXC-AS1 overexpression plasmid-activated Wnt

methodsFocusing on the occurrence and progression of gastric cancer, the human gastric cancer cell line BGC823 (University Experimental Center) was taken as the research object and was transfected after subculture. According to the different ways of transfection, the cells were divided into the P1 group (LV-eIF4AIII-RNAi (44682-1) overexpressed plasmid), the P2 group (pcDNA-HOXC-AS1 overexpressed plasmid), the P3 group (LV-eIF4AIII-RNAi (44682-1) + pcDNA-HOXC-AS1), and the P4 group (no transfection, control group). Cell proliferation was detected by CCK-8 (Cell Counting Kit-8) assay, Western blotting was adopted to detect Wnt3a and P-GSK3

resultsThe results show that the protein expression levels of Wnt3a and P-GSK3

conclusionThe 73HOXC-AS1 overexpression plasmid-activated Wnt

Indexed as

Disease ProgressionWnt Signaling PathwayApoptosisCell CycleCell Line, TumorCell MovementCell ProliferationCell SurvivalClone CellsEukaryotic Initiation Factor-4AGlycogen Synthase Kinase 3 betaHumansNeoplasm InvasivenessPhosphorylationRNA, Long NoncodingStomach NeoplasmsEukaryotic Initiation Factor-4AGlycogen Synthase Kinase 3 betaRNA, Long Noncoding

Identifiers

PMID33954199
PMCPMC8064778
OpenAlexW3156637273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.