Evidence map›Paper›PMID 33954190›Full record

ArticleBioMed research international2021

MicroRNA Biomarkers of High-Grade Cervical Intraepithelial Neoplasia in Liquid Biopsy.

Rhafaela L Causin, Luciane S da Silva, Adriane F Evangelista, Letícia F Leal, Karen C B Souza, Danielle Pessôa-Pereira, Graziela M Matsushita, Rui M Reis, José H T G Fregnani, Márcia M C Marques

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  7. A dexterous fluorescence sensor for diversified-biomarker detection using cyclic EDC-CHA (EDCHA) system.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Article
  8. Review
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  15. The microRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Article
  18. Upregulated miRNAs on theFrontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Rhafaela L CausinMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784-400, Brazil.
Luciane S da SilvaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784-400, Brazil.
Adriane F EvangelistaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784-400, Brazil.
Letícia F LealMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784-400, Brazil.
Karen C B SouzaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784-400, Brazil.
Danielle Pessôa-PereiraMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784-400, Brazil.
Graziela M MatsushitaDepartment of Pathology, Barretos Cancer Hospital, Barretos, SP 14784-400, Brazil.
Rui M ReisMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784-400, Brazil.
José H T G FregnaniA. C. Camargo Cancer Center, São Paulo, SP 01509-010, Brazil.
Márcia M C MarquesMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP 14784-400, Brazil.ORCID https://orcid.org/0000-0001-5616-6710
Hospital de Câncer de Barretos · BRAC Camargo Hospital · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New prevention strategies are needed to detect cervical intraepithelial neoplasia (CIN). The microRNA expression analysis has already been reported as molecular biomarkers in the early detection of cervical cancer (CC) through minimally invasive samples, such as liquid biopsy, obtained through collection using liquid-based cytology (LBC). In this study, we aimed to identify molecular signatures of microRNAs in cervical precursor lesions from LBC cervical and the molecular pathways potentially associated with the CC progression. We analyzed 31 LBC cervical samples from women who underwent colposcopy. These samples were divided into two groups: the first group was composed of samples without precursor lesions of CC, considering the control group, referred to as healthy female subjects (HFS;

Indexed as

AdultAgedArea Under CurveBiomarkers, TumorCervix UteriComputer SimulationDown-RegulationFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLiquid BiopsyLogistic ModelsMicroRNAsMiddle AgedNeoplasm GradingBiomarkers, TumorMicroRNAsRNA, Messenger

Identifiers

PMID33954190
PMCPMC8060087
OpenAlexW3154076067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.