Evidence map›Paper›PMID 33954148›Full record

ArticleJournal of orthopaedic case reports

Compartment Syndrome of the Thigh in a Patient with Fibrodysplasia Ossificans Progressiva.

Frederick S Kaplan, Mona Al Mukaddam, Robert J Pignolo

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of orthopaedic case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Frederick S KaplanDepartment of Orthopaedic Surgery, The Perelman School of Medicine of The University of Pennsylvania, Philadelphia, PA 19104, USA.
Mona Al MukaddamDepartment of Orthopaedic Surgery, The Perelman School of Medicine of The University of Pennsylvania, Philadelphia, PA 19104, USA.
Robert J PignoloDepartment of Medicine, The Mayo Clinic, Rochester, MN 55905, USA.
University of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe severe pain that commonly accompanies appendicular flare-ups of fibrodysplasia ossificans progressiva (FOP) is often ascribed to compartment syndrome, but no documentation exists. CASE REPORT: We revisited the case of an adult with classic FOP who underwent measurement of compartment pressure of the thigh during an acute, severely painful flare-up of the thigh. The intracompartmental pressure of the thigh was measured at 95--110 mm of mercury (normal compartment pressure is 0--8 mmHg). A fasciotomy of the thigh was performed. Despite immediate post-operative relief of pain, progressive heterotopic ossification and loss of function of the hip and knee occurred.

conclusionThis unique case documents and confirms the suspected presence of compartment syndrome during an acute flare-up of FOP and has vital implications for understanding the pathophysiology and care of patients with acute appendicular flare-ups of FOP and for the design of emerging clinical trials.

Indexed as

activin receptor Abone morphogenetic protein signalingcompartment syndromeFibrodysplasia ossificans progressivaa (FOP)heterotopic ossificationtype I (ACVR1)

Identifiers

PMID33954148
PMCPMC8051568
OpenAlexW3158107055

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.