Evidence map›Paper›PMID 33953964›Full record

ArticleJournal of ophthalmology2021

The Role of Intravitreal Anti-VEGF Agents in Rabbit Eye Model of Open-Globe Injury.

Xiao Zhao, Han Han, Yinting Song, Mei Du, Mengyu Liao, Xue Dong, Xiaohong Wang, Ferenc Kuhn, Annette Hoskin, Heping Xu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Xiao ZhaoDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
Han HanDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
Yinting SongDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
Mei DuLaboratory of Molecular Ophthalmology, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Mengyu LiaoDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
Xue DongDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
Xiaohong WangLaboratory of Molecular Ophthalmology, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Ferenc KuhnHelen Keller Foundation for Research and Education, Birmingham, AL, USA.
Annette HoskinSave Sight Institute, The University of Sydney, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-7732-0323
Heping XuCentre for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Hua YanDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.ORCID https://orcid.org/0000-0002-7651-840X
Tianjin Medical University General Hospital · CNTianjin Medical University · CNHelen Keller Eye Research Foundation · USLions Eye Institute · AUQueen's University Belfast · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effects of intravitreal anti-VEGF agents in a rabbit model of open-globe injury (OGI).

methodsOGI was induced in the right eyes of 75 Belgian rabbits by making 5 mm circumferential incision placed 6 mm behind the limbus. The rabbits were divided into 4 groups: control (

resultsVitreous levels of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-

conclusionAnti-VEGF treatments after OGI significantly attenuated the upregulation of growth factors and cytokines in the vitreous and prevented intravitreal proliferation and epiretinal scar formation and thus may protect against the development of posttraumatic complications such as proliferative vitreoretinopathy (PVR).

Identifiers

PMID33953964
PMCPMC8064804
OpenAlexW3155825218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.