Evidence map›Paper›PMID 33953926›Full record

ArticleIUCrJ2021

Rapid response to emerging biomedical challenges and threats.

Marek Grabowski, Joanna M Macnar, Marcin Cymborowski, David R Cooper, Ivan G Shabalin, Miroslaw Gilski, Dariusz Brzezinski, Marcin Kowiel, Zbigniew Dauter, Bernhard Rupp and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUCrJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Duplicate entries in the Protein Data Bank: how to detect and handle them.Acta crystallographica. Section D, Structural biology · 2025
    Article
  2. Towards a dependable data set of structures for L-asparaginase research.Acta crystallographica. Section D, Structural biology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marek GrabowskiDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-8072-4919
Joanna M MacnarDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0003-1760-2668
Marcin CymborowskiDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA.
David R CooperDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0001-5240-9789
Ivan G ShabalinDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0003-3955-9242
Miroslaw GilskiDepartment of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Poznan, Poland.ORCID https://orcid.org/0000-0002-3941-9947
Dariusz BrzezinskiDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0001-9723-525X
Marcin KowielCenter for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.ORCID https://orcid.org/0000-0002-6269-3151
Zbigniew DauterCenter for Structural Biology, National Cancer Institute, Frederick, Maryland, USA.ORCID https://orcid.org/0000-0002-8806-9066
Bernhard Ruppk.-k Hofkristallamt, San Diego, California, USA.ORCID https://orcid.org/0000-0002-3300-6965
Alexander WlodawerCenter for Structural Biology, National Cancer Institute, Frederick, Maryland, USA.ORCID https://orcid.org/0000-0002-5510-9703
Mariusz JaskolskiDepartment of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Poznan, Poland.ORCID https://orcid.org/0000-0003-1587-6489
Wladek MinorDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0001-7075-7090

Funding

Protein StructureZIABC010348 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WLODAWER, ALEXANDER · 2009 to 2025
$27.5M
Reproducible, Unbiased Ligand Identification Assisted by Artificial Intelligence and Development of Ligand Reference LibrariesR01GM132595 · NIGMS · UNIVERSITY OF VIRGINIA · PI MINOR, WLADEK · 2019 to 2022
$2.3M
NIGMS NIH HHS R01 GM132595
6 · The paper itself

Abstract

As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have been deposited in the Protein Data Bank within less than a year. The avalanche of new structural data has given rise to multiple resources dedicated to assessing the correctness and quality of structural data and models. Here, an approach to evaluate the massive amounts of such data using the resource https://covid19.bioreproducibility.org is described, which offers a template that could be used in large-scale initiatives undertaken in response to future biomedical crises. Broader use of the described methodology could considerably curtail information noise and significantly improve the reproducibility of biomedical research.

Indexed as

bioreproducibilitycoronavirusCOVID-19information noisepandemicSARS-COV-2

Identifiers

PMID33953926
PMCPMC8086160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.