Evidence map›Paper›PMID 33953924›Full record

ArticleIUCrJ2021

Structural insights into protein folding, stability and activity using

Joao Ramos, Valerie Laux, Michael Haertlein, Elisabetta Boeri Erba, Katherine E McAuley, V Trevor Forsyth, Estelle Mossou, Sine Larsen, Annette E Langkilde

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUCrJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Secondary Structure of HumanFrontiers in oncology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Joao RamosLife Sciences Group, Institut Laue-Langevin, 71 Avenue des Martyrs, 38000 Grenoble, France.ORCID https://orcid.org/0000-0002-1473-9303
Valerie LauxLife Sciences Group, Institut Laue-Langevin, 71 Avenue des Martyrs, 38000 Grenoble, France.ORCID https://orcid.org/0000-0002-8402-1997
Michael HaertleinLife Sciences Group, Institut Laue-Langevin, 71 Avenue des Martyrs, 38000 Grenoble, France.ORCID https://orcid.org/0000-0001-5410-0638
Elisabetta Boeri ErbaPartnership for Structural Biology (PSB), 71 Avenue des Martyrs, 38000 Grenoble, France.ORCID https://orcid.org/0000-0002-5910-4707
Katherine E McAuleyDiamond Light Source, Didcot OX11 0DE, United Kingdom.ORCID https://orcid.org/0000-0002-9545-072X
V Trevor ForsythLife Sciences Group, Institut Laue-Langevin, 71 Avenue des Martyrs, 38000 Grenoble, France.ORCID https://orcid.org/0000-0003-0380-3477
Estelle MossouLife Sciences Group, Institut Laue-Langevin, 71 Avenue des Martyrs, 38000 Grenoble, France.ORCID https://orcid.org/0000-0002-1899-4942
Sine LarsenDepartment of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-3848-1789
Annette E LangkildeDepartment of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2467-4205
Institut Laue-Langevin · FRUniversity of Copenhagen · DKCentre National de la Recherche Scientifique · FRPaul Scherrer Institute · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This structural and biophysical study exploited a method of perdeuterating hen egg-white lysozyme based on the expression of insoluble protein in

Indexed as

biophysical characterizationHEWLisotope effectperdeuterated lysozymeprotein refoldingprotein structurestructural biologyX-ray crystallography

Identifiers

PMID33953924
PMCPMC8086161
OpenAlexW3133816360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.