ArticleIranian journal of basic medical sciences2021
Lettuce-avicularin treatment reverses insulin resistance through stimulation of glycolytic kinases and insulin signaling molecules.
Article in Iranian journal of basic medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Polyphenol-rich Chinese olive extracts attenuate lipid accumulation in HepG2 cells, accompanied by AMPK phosphorylation and miRNA alterations.Frontiers in nutrition · 2026Article
- A Comprehensive Review of the Effects ofPreventive nutrition and food science · 2025Review
- Avicularin Attenuated Lead-Induced Ferroptosis, Neuroinflammation, and Memory Impairment in Mice.Antioxidants (Basel, Switzerland) · 2024Article
- Virtual Screening of Soybean Protein Isolate-Binding Phytochemicals and Interaction Characterization.Foods (Basel, Switzerland) · 2023Article
- Avicularin Attenuates Lead-Induced Impairment of Hepatic Glucose Metabolism by Inhibiting the ER Stress-Mediated Inflammatory Pathway.Nutrients · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
objectivesIn order to recommend a more effective approach to manage insulin resistance, we monitored the activities of glycolytic kinases, insulin signaling molecules, and incretin hormones and identified the possible targets related to the insulin-sensitizing effects of combined pharmacological and dietary intervention involving avicularin and lettuce. MATERIALS AND
methodsInsulin resistance was induced in rats with a fructose-rich diet and confirmed from baseline analysis of FBS (>250 mg/dl), insulin (>25 µIU/ml), and HOMA-IR (>10). For 12 weeks, the insulin-resistant rats were treated exclusively with 5000 mg/kg b.w avicularin (DAvi) or by dietary placement on lettuce (DLet) or a combination of both and compared with non-insulin resistant rats.
resultsAvicularin reversed alterations in HbA1c and insulin levels. DLet produced no significant effect on the incretins GLP 1 (
conclusionA combined pharmacological and dietary approach with avicularin and lettuce is required to effectively reverse insulin resistance.
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