Trial reportNeural plasticity2021
Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors.
Trial report in Neural plasticity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- A meta-analysis of the effects of transcranial direct current stimulation combined with cognitive training on working memory in healthy older adults.Frontiers in aging neuroscience · 2024Pooled it
- Cognitive potency and safety of tDCS treatment for major depressive disorder: a systematic review and meta-analysis.Frontiers in human neuroscience · 2024Pooled it
- Enhanced cognitive performance in older adults through combined cognitive training and transcranial direct current stimulation.Scientific reports · 2025Trial
- Asymmetric Modulation of Brain Connectivity by Anodal Transcranial Direct Current Stimulation in Healthy Individuals: A Single-Blind, Randomized Sham-Controlled Trial.Human brain mapping · 2025Trial
- tDCS-enhanced cognitive training improves attention and alters connectivity in control and somatomotor networks: A triple blind study.NeuroImage · 2024Trial
- Exploring the impact of intensified multiple session tDCS over the left DLPFC on brain function in MCI: a randomized control trial.Scientific reports · 2024Trial
- Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS.Scientific reports · 2022Trial
- Effectiveness of Transcranial Stimulation on Cognitive Abilities of Older Adults with Mild Cognitive Impairment.Journal of clinical medicine · 2025Review
- Transcranial direct current stimulation and neuronal functional connectivity in MCI: role of individual factors associated to AD.Frontiers in psychiatry · 2024Article
- Impact of twice-a-day transcranial direct current stimulation intervention on cognitive function and motor cortex plasticity in patients with Alzheimer's disease.General psychiatry · 2023Article
- Strategies to Promote Cognitive Health in Aging: Recent Evidence and Innovations.Current psychiatry reports · 2022Review
- Modulation of network centrality and gray matter microstructure using multi-session brain stimulation and memory training.Human brain mapping · 2022Article
- Contribution of the multi-echo approach in accelerated functional magnetic resonance imaging multiband acquisition.Human brain mapping · 2022Article
- Efficacy of Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex in Patients With Minimally Conscious State.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enhancing cognitive functions through noninvasive brain stimulation is of enormous public interest, particularly for the aging population in whom processes such as working memory are known to decline. In a randomized double-blind crossover study, we investigated the acute behavioral and neural aftereffects of bifrontal and frontoparietal transcranial direct current stimulation (tDCS) combined with visual working memory (VWM) training on 25 highly educated older adults. Resting-state functional connectivity (rs-FC) analysis was performed prior to and after each stimulation session with a focus on the frontoparietal control network (FPCN). The bifrontal montage with anode over the left dorsolateral prefrontal cortex enhanced VWM accuracy as compared to the sham stimulation. With the rs-FC within the FPCN, we observed significant stimulation × time interaction using bifrontal tDCS. We found no cognitive aftereffects of the frontoparietal tDCS compared to sham stimulation. Our study shows that a single bifrontal tDCS combined with cognitive training may enhance VWM performance and rs-FC within the relevant brain network even in highly educated older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.