Evidence map›Paper›PMID 33953722›Full record

ReviewFrontiers in immunology2021

Host-Directed Therapies: Modulating Inflammation to Treat Tuberculosis.

Stefanie Krug, Sadiya Parveen, William R Bishai

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 78 citations in OpenAlex.

  1. Randomized Trial of Metformin With Anti-Tuberculosis Drugs for Early Sputum Conversion in Adults With Pulmonary Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Structure-based virtual screening andMicrobiology spectrum · 2024
    Article
  20. Current medicinal chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Stefanie KrugDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Sadiya ParveenDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
William R BishaiDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Glutamine metabolism inhibitors for TB and TB-HIV: dual action as host-directed therapies with antibacterial activityR01AI155602 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2020 to 2024
$4.0M
Targeted cell-depleting immunotherapy for TB and HIVR01AI152688 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2020 to 2024
$3.4M
Targeted Immunotherapy for Tuberculosis and HIV co-infectionR21AI130595 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2017 to 2018
$449k
Dissecting the role of host enzyme PARP1 in tuberculosis infection and therapyF31HL140812 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KRUG, STEFANIE MARIA HELENA · 2018 to 2019
$90k
NHLBI NIH HHS F31 HL140812NIAID NIH HHS R01 AI152688NIAID NIH HHS R01 AI155602NIAID NIH HHS R21 AI130595
6 · The paper itself

Abstract

Following infection with

Indexed as

Anti-Inflammatory AgentsAntitubercular AgentsClinical Trials as TopicDrug RepositioningHost-Pathogen InteractionsHumansInflammationMycobacterium tuberculosisSignal TransductionTuberculosisTuberculosis, PulmonaryAnti-Inflammatory AgentsAntitubercular Agentsdiphtheria fusion protein toxinhost-directed therapiesimmunotherapyMDSCsMMPs (metalloproteinases)PARP inhibition (PARPi)tuberculosis

Identifiers

PMID33953722
PMCPMC8089478
OpenAlexW3153343139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.