Evidence map›Paper›PMID 33953681›Full record

ArticleFrontiers in pharmacology2021

Insight into the Role of the STriatal-Enriched Protein Tyrosine Phosphatase (STEP) in A

Maria Rosaria Domenici, Cinzia Mallozzi, Rita Pepponi, Ida Casella, Valentina Chiodi, Antonella Ferrante, Patrizia Popoli

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maria Rosaria DomeniciNational Centre for Drug Research and Evaluation, Istituto Superiore di Sanitá, Rome, Italy.
Cinzia MallozziDepartment of Neuroscience, Istituto Superiore di Sanità, Rome, Italy.
Rita PepponiNational Centre for Drug Research and Evaluation, Istituto Superiore di Sanitá, Rome, Italy.
Ida CasellaNational Centre for Drug Research and Evaluation, Istituto Superiore di Sanitá, Rome, Italy.
Valentina ChiodiNational Centre for Drug Research and Evaluation, Istituto Superiore di Sanitá, Rome, Italy.
Antonella FerranteNational Centre for Drug Research and Evaluation, Istituto Superiore di Sanitá, Rome, Italy.
Patrizia PopoliNational Centre for Drug Research and Evaluation, Istituto Superiore di Sanitá, Rome, Italy.
Istituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The STriatal-Enriched protein tyrosine phosphatase STEP is a brain-specific tyrosine phosphatase that plays a pivotal role in the mechanisms of learning and memory, and it has been demonstrated to be involved in several neuropsychiatric diseases. Recently, we found a functional interaction between STEP and adenosine A

Indexed as

adenosine A2A receptorbrainfunctional interactionSH-SY5Y neuroblastoma cell linesstriatal-enriched protein tyrosine phosphatase

Identifiers

PMID33953681
PMCPMC8090931
OpenAlexW3153061583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.