Evidence map›Paper›PMID 33953628›Full record

ArticleEye and brain2021

Portable Diagnostic System for Age-Related Macular Degeneration Screening Using Visual Evoked Potentials.

Craig Versek, S Mohammad Ali Banijamali, Peter Bex, Kameran Lashkari, Sagar Kamarthi, Srinivas Sridhar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye and brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  6. Visual Evoked Potentials for the Detection of Diabetic Retinal Neuropathy.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Craig VersekNeuroFieldz Inc, Newton, MA, USA.ORCID 0000-0003-3553-4355
S Mohammad Ali BanijamaliDepartment of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
Peter BexDepartment of Psychology, Northeastern University, Boston, MA, USA.
Kameran LashkariDepartment of Bioengineering, University of Massachusetts Dartmouth, Dartmouth, MA, USA.
Sagar KamarthiDepartment of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
Srinivas SridharNeuroFieldz Inc, Newton, MA, USA.
Northeastern University · USNeuroMetrix (United States) · USUniversity of Massachusetts Dartmouth · US

Funding

Neuro-Optical Diagnostic System for Macular DegenerationR44AG057250 · NIA · NEUROFIELDZ, INC. · PI VERSEK, CRAIG · 2020 to 2022
$2.0M
Eye Movement Rehabilitation in Low Vision PatientsR01EY029713 · NEI · NORTHEASTERN UNIVERSITY · PI BEX, PETER JOHN · 2019 to 2023
$1.9M
Neuro-Optical Diagnostic System for Macular DegenerationR41AG057250 · NIA · NEUROFIELDZ, INC. · PI SRIDHAR, SRINIVAS · 2017 to 2017
$225k
NEI NIH HHS R01 EY029713NIA NIH HHS R41 AG057250NIA NIH HHS R44 AG057250
6 · The paper itself

Abstract

backgroundDelayed Dark-Adapted vision Recovery (DAR) is a biomarker for Age-related Macular Degeneration (AMD), however its measurement is burdensome for patients and examiners.

methodsIn this study, we developed a portable, wireless and user-friendly system that employs a headset with a smartphone to deliver controlled photo-bleach and monocular pattern reversal stimuli, while using custom electroencephalography (EEG) electrodes and electronics in order to measure Dark-Adapted Visual Evoked Potentials (DAVEP) objectively and separately at the peripheral and central visual field. This is achieved in one comfortable 20-minute session, without requiring subject reporting. DAVEP responses post photo-bleach for up to 15 minutes were measured concurrently from both eyes in 12 AMD-patients, 1 degenerative myopia patient, and 8 controls who had no diagnosed macular vision loss.

resultsRobust positive polarity DAVEP responses were observed at 200-500 ms from stimulus onset to scotopic stimuli that have been seldom reported and analyzed previously. The amplitude recovery of the DAVEP response was significantly delayed in AMD patients as compared to controls. We developed DAVEP1 scores, a simple metric for DAR, which classified 90% of subject eyes correctly, indicating the presence of AMD in at least one eye of all pre-confirmed subjects with this diagnosis.

conclusionWe developed a user-friendly, portable VEP system and DAVEP1 metric, which show a high potential to identify DAR-deficits in AMD-patients. This novel technology could aid in early diagnosis of AMD.

Indexed as

age-related macular degenerationdark adaptation recoveryEEGportable diagnosticsscotopic visionvisual evoked potential

Identifiers

PMID33953628
PMCPMC8092944
OpenAlexW3157102154

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.