Evidence map›Paper›PMID 33953396›Full record

ArticleNature2021

Response of the microbiome-gut-brain axis in Drosophila to amino acid deficit.

Boram Kim, Makoto I Kanai, Yangkyun Oh, Minsoo Kyung, Eun-Kyoung Kim, In-Hwan Jang, Ji-Hoon Lee, Sang-Gyu Kim, Greg S B Suh, Won-Jae Lee

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 126 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Diversity of theMicrobiology spectrum · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Gut metabolism links precision nutrition, exercise, and healthspan inbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Gut-brain communication in Drosophila melanogaster.Current opinion in neurobiology · 2025
    Review
  13. Article
  14. Stress-induced preference for antioxidants byProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Boram Kim *National Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-4786-6675
Makoto I Kanai *Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University Grossman School of Medicine, New York, NY, USA.
Yangkyun OhSkirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University Grossman School of Medicine, New York, NY, USA.
Minsoo KyungNational Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Eun-Kyoung KimNational Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
In-Hwan JangNational Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Ji-Hoon LeeNational Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Sang-Gyu KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0003-2574-3233
Greg S B SuhDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. seongbaesuh@kaist.ac.kr.ORCID http://orcid.org/0000-0003-4381-658X
Won-Jae LeeNational Creative Research Initiative Center for Hologenomics and School of Biological Sciences, Seoul National University, Seoul, Republic of Korea. lwj@snu.ac.kr.ORCID http://orcid.org/0000-0002-1438-8005
Seoul National University · KRKorea Advanced Institute of Science and Technology · KRNew York University · US

Funding

Understanding the role of the brain CRH (Corticotropin-Releasing Hormone) system in the detection and consumption of nutritional sugar.R01DK106636 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RYOO, HYUNG D · 2015 to 2019
$1.9M
Characterization of Taste-independent Sugar Sensor in the BrainR01DK116294 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RYOO, HYUNG D · 2018 to 2021
$1.7M
NIDDK NIH HHS R01 DK106636NIDDK NIH HHS R01 DK116294
6 · The paper itself

Abstract

A balanced intake of macronutrients-protein, carbohydrate and fat-is essential for the well-being of organisms. An adequate calorific intake but with insufficient protein consumption can lead to several ailments, including kwashiorkor

Indexed as

Brain-Gut AxisFood PreferencesGastrointestinal MicrobiomeAmino Acids, EssentialAnimal Nutritional Physiological PhenomenaAnimalsAnimals, Genetically ModifiedAppetiteDrosophilaEnterocytesFemaleGerm-Free LifeHungerLeucineSymbiosisAmino Acids, EssentialLeucine

Identifiers

PMID33953396
OpenAlexW3159072427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.