Evidence map›Paper›PMID 33953369›Full record

ReviewNature reviews. Cancer2021

Long noncoding RNAs in cancer metastasis.

S John Liu, Ha X Dang, Daniel A Lim, Felix Y Feng, Christopher A Maher

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 394 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
394citing papers in PubMed, 3 pooled it
55.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

394 citing papers in PubMed, 3 syntheses or guidelines pooled it, 698 citations in OpenAlex.

  1. Pooled it
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  14. Advances in antisense oligonucleotide treatment for cancer.Japanese journal of clinical oncology · 2026
    Review
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  17. Review
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334 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

S John LiuDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1042-0191
Ha X DangDepartment of Internal Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-9342-9249
Daniel A LimDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Felix Y FengDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Christopher A MaherDepartment of Internal Medicine, Washington University in St Louis, St Louis, MO, USA. christophermaher@wustl.edu.ORCID http://orcid.org/0000-0002-9035-603X
James S. McDonnell Foundation · USUniversity of California, San Francisco · USSan Francisco VA Medical Center · US

Funding

Functional long noncoding RNAs in neural developmentR01NS124881 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL A LIM · 2022 to 2026
$3.0M
Long noncoding RNA regulation of neural stem cellsR01NS091544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2016 to 2020
$1.7M
Functional long noncoding RNAs in human gliomaR21NS101395 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2017 to 2018
$436k
NINDS NIH HHS R01 NS091544NINDS NIH HHS R01 NS124881NINDS NIH HHS R21 NS101395
6 · The paper itself

Abstract

Metastasis is a major contributor to cancer-associated deaths. It is characterized by a multistep process that occurs through the acquisition of molecular and phenotypic changes enabling cancer cells from a primary tumour to disseminate and colonize at distant organ sites. Over the past decade, the discovery and characterization of long noncoding RNAs (lncRNAs) have revealed the diversity of their regulatory roles, including key contributions throughout the metastatic cascade. Here, we review how lncRNAs promote metastasis by functioning in discrete pro-metastatic steps including the epithelial-mesenchymal transition, invasion and migration and organotrophic colonization, and by influencing the metastatic tumour microenvironment, often by interacting within ribonucleoprotein complexes or directly with other nucleic acid entities. We discuss well-characterized lncRNAs with in vivo phenotypes and highlight mechanistic commonalities such as convergence with the TGFβ-ZEB1/ZEB2 axis or the nuclear factor-κB pathway, in addition to lncRNAs with controversial mechanisms and the influence of methodologies on mechanistic interpretation. Furthermore, some lncRNAs can help identify tumours with increased metastatic risk and spur novel therapeutic strategies, with several lncRNAs having shown potential as novel targets for antisense oligonucleotide therapy in animal models. In addition to well-characterized examples of lncRNAs functioning in metastasis, we discuss controversies and ongoing challenges in lncRNA biology. Finally, we present areas for future study for this rapidly evolving field.

Indexed as

AnimalsCell MovementEpithelial-Mesenchymal TransitionHumansNeoplasm InvasivenessNeoplasm MetastasisRNA, Long NoncodingTumor MicroenvironmentH19 long non-coding RNAHOTAIR long untranslated RNA, humanMALAT1 long non-coding RNA, humanRNA, Long Noncoding

Identifiers

PMID33953369
PMCPMC8288800
OpenAlexW3159024074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.