Evidence map›Paper›PMID 33953356›Full record

SynthesisPediatric research2022

Brain proton magnetic resonance spectroscopy and neurodevelopment after preterm birth: a systematic review.

Burcu Cebeci, Thomas Alderliesten, Jannie P Wijnen, Niek E van der Aa, Manon J N L Benders, Linda S de Vries, Agnes van den Hoogen, Floris Groenendaal

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. The neuroradiology journal · 2022
    Pooled it
  3. Article
  4. Cerebral magnetic resonance spectroscopy - insights into preterm brain injury.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 3 countries.

Burcu CebeciDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Thomas AlderliestenDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Jannie P WijnenDepartment of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Niek E van der AaDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Manon J N L BendersDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Linda S de VriesDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Agnes van den HoogenDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Floris GroenendaalDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands. F.Groenendaal@umcutrecht.nl.ORCID http://orcid.org/0000-0002-9284-1637
Utrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreterm infants are at risk of neurodevelopmental impairments. At present, proton magnetic resonance spectroscopy (

methodsPubMed and Embase were searched to identify studies using

resultsTwenty papers evaluated

conclusionsNAA/Cho in WM assessed at term-equivalent age was associated with motor, cognitive, and language outcome, and NAA/Cho in deep GM was associated with language outcome at 18-24 months CA. IMPACT: In preterm born infants, brain metabolism assessed using

Indexed as

Premature BirthAdolescentAspartic AcidBrainCholineFemaleHumansInfantInfant, NewbornInfant, PrematureMagnetic Resonance ImagingMagnetic Resonance SpectroscopyProton Magnetic Resonance SpectroscopyProtonsAspartic AcidCholineProtons

Identifiers

PMID33953356
OpenAlexW3158099122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.