Evidence map›Paper›PMID 33953250›Full record

ArticleScientific reports2021

Determinants of loss to care and risk of clinical progression in PLWH who are re-engaged in care after a temporary loss.

Cristina Mussini, Patrizia Lorenzini, Alessandro Cozzi-Lepri, Alessia Mammone, Giovanni Guaraldi, Giulia Marchetti, Miriam Lichtner, Giuseppe Lapadula, Sergio Lo Caputo, Andrea Antinori and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cristina MussiniInfectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Patrizia LorenziniNational Institute for Infectious Diseases 'L. Spallanzani', Via Portuense 292, 00149, Rome, Italy. patrizia.lorenzini@inmi.it.
Alessandro Cozzi-LepriInstitute for Global Health, UCL, London, UK.
Alessia MammoneNational Institute for Infectious Diseases 'L. Spallanzani', Via Portuense 292, 00149, Rome, Italy.
Giovanni GuaraldiInfectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Giulia MarchettiClinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy.
Miriam LichtnerDepartment of Public Health and Infectious Diseases Unit, Sapienza University of Rome, Polo Pontino, Latina, Italy.
Giuseppe LapadulaDivision of Infectious Diseases, San Gerardo Hospital, Monza, Italy.
Sergio Lo CaputoClinic of Infectious Diseases, University of Foggia, Foggia, Italy.
Andrea AntinoriNational Institute for Infectious Diseases 'L. Spallanzani', Via Portuense 292, 00149, Rome, Italy.
Antonella d'Arminio MonforteClinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy.
Enrico GirardiNational Institute for Infectious Diseases 'L. Spallanzani', Via Portuense 292, 00149, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk of developing AIDS is elevated not only among those with a late HIV diagnosis but also among those lost to care (LTC). The aims were to address the risk of becoming LTC and of clinical progression in LTC patients who re-enter care. Patients were defined as LTC if they had no visit for ≥ 18 months. Of these, persons with subsequent visits were defined as re-engaged in care (RIC). Factors associated with becoming LTC and RIC were investigated. The risk of disease progression was estimated by comparing RIC with patients continuously followed. Over 11,285 individuals included, 3962 became LTC, and of these, 1062 were RIC. Older age, presentation with AIDS and with higher HIV-RNA were associated with a reduced risk of LTC. In contrast, lower education level, irregular job, being an immigrant and injecting-drug user were associated with an increased LTC probability. Moreover, RIC with HIV-RNA > 200 copies/mL at the re-entry had a higher risk of clinical progression, while those with HIV-RNA ≤ 200 copies/mL had a higher risk of only non-AIDS progression. Patients re-entering care after being LTC appeared to be at higher risk of clinical progression than those continuously in care. Active strategies for re-engagement in care should be promoted.

Indexed as

HIV InfectionsLost to Follow-UpAdolescentAdultDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedYoung Adult

Identifiers

PMID33953250
PMCPMC8099893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.