ArticleNature communications2021
A dual-target molecular mechanism of pyrethrum repellency against mosquitoes.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Repellent effects of insecticides against Aedes aegypti: a systematic review.Parasites & vectors · 2025Pooled it
- Chemical Composition and Biological Activities of Croton sertanejus Essential Oil Against Aedes aegypti and Preliminary Toxicity in Mus Musculus.Chemistry & biodiversity · 2026Article
- Commercial permethrin elicits chemoreceptive responses on different Anopheles gambiae sensory appendages.Pest management science · 2026Article
- Developmental Consequences of Early-Life Exposure and Adulticidal Effects ofMolecules (Basel, Switzerland) · 2026Article
- A microbial platform for selective biosynthesis of monoterpene esters.Nature communications · 2026Article
- Impact of Pyrethroid Resistance on the Intrinsic Insecticidal Activities of Geraniol Against the Yellow Fever Mosquito,Insects · 2026Article
- Sensory coding of borneol repellency in culicine mosquitoes via the Or49 pathway.Nature communications · 2026Article
- Impact of olfactory sensitivity preferences on midgut pathophysiology of Aedes mosquitoes towards different sugar variants.Parasitology research · 2026Article
- Botanical defence: medicinal plants as botanical insecticides againstFrontiers in insect science · 2026Review
- Involvement of Multiple Ion Channels and Receptors in Mediating the Insecticidal and Repellent Actions of Limonene.International journal of molecular sciences · 2025Article
- Odor repellency and neuronal responses of commercial products towards Anopheles mosquitoes.Malaria journal · 2025Article
- Article
- The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission.Parasites & vectors · 2025Review
- NlugOBP1 in Nilaparvata lugens involved in the perception of repellent agent geraniol.Scientific reports · 2025Article
- Article
- Article
- Making scents of mosquito repellents.Trends in parasitology · 2025Review
- HL-IR mediates cinnamaldehyde repellency behavior in parthenogenetic Haemaphysalis longicornis.PLoS neglected tropical diseases · 2025Article
- A conserved odorant receptor underpins borneol-mediated repellency in culicine mosquitoes.bioRxiv : the preprint server for biology · 2024Article
- Non-contact detection of pyrethroids widely used in vector control by Anopheles mosquitoes.PloS one · 2024Article
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 4 countries.
Funding
Abstract
Pyrethrum extracts from flower heads of Chrysanthemum spp. have been used worldwide in insecticides and repellents. While the molecular mechanisms of its insecticidal action are known, the molecular basis of pyrethrum repellency remains a mystery. In this study, we find that the principal components of pyrethrum, pyrethrins, and a minor component, (E)-β-farnesene (EBF), each activate a specific type of olfactory receptor neurons in Aedes aegypti mosquitoes. We identify Ae. aegypti odorant receptor 31 (AaOr31) as a cognate Or for EBF and find that Or31-mediated repellency is significantly synergized by pyrethrin-induced activation of voltage-gated sodium channels. Thus, pyrethrum exerts spatial repellency through a novel, dual-target mechanism. Elucidation of this two-target mechanism may have potential implications in the design and development of a new generation of synthetic repellents against major mosquito vectors of infectious diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.