Evidence map›Paper›PMID 33952725›Full record

ArticleAging2021

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer.

Bo Yang, Fei Teng, Liang Chang, Jian Wang, De-Long Liu, Yong-Sheng Cui, Guang-Hu Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bo YangDepartment of Thoracic Surgery, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin, China.
Fei TengKey Laboratory for Biorheological Science and Technology of Ministry of Education, Chongqing University Cancer Hospital, Shapingba, Chongqing, China.
Liang ChangDepartment of Thoracic Surgery, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin, China.
Jian WangDepartment of Neurovascular Surgery, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin, China.
De-Long LiuDepartment of Thoracic Surgery, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin, China.
Yong-Sheng CuiDepartment of Thoracic Surgery, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin, China.
Guang-Hu LiDepartment of Thoracic Surgery, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are messengers for intercellular communication and signal transduction. Circular RNA (circRNA) abnormal expression and regulation are involved in the occurrence and development of a variety of tumors. In the present study, exosomes in the serum of five patients with non-small cell lung cancer (NSCLC) were isolated before and after EGFR-TKIs resistance, and the circRNA expression profile was screened using a circRNA microarray. The effects of the exosome circRNA_102481 on cell proliferation and apoptosis were analyzed. The interaction between miR-30a-5p and circRNA_102481 or ROR1 was predicted by starBase software, and was confirmed by RNA pull-down and dual-luciferase reporter assays. The results showed that exosomes containing circRNA_102481 were significantly up-regulated in NSCLC with EGFR-TKIs resistance (p<0.05), and that circRNA_102481 was mainly secreted by EGFR-TKIs resistance cell via exosomes (p<0.05). Both circRNA_102481 silencing and si-circRNA_102481 transported by exosomes could inhibit EGFR-TKIs resistance cell proliferation and promote cell apoptosis and circRNA_102481 overexpression could promote EGFR-TKIs sensitive cell proliferation and inhibit cell apoptosis

Indexed as

Carcinoma, Non-Small-Cell LungCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansLung NeoplasmsMicroRNAsReceptor Tyrosine Kinase-like Orphan ReceptorsRNA, CircularMicroRNAsMIRN30a microRNA, humanReceptor Tyrosine Kinase-like Orphan ReceptorsRNA, CircularROR1 protein, humancircRNA_102481EGFR-TKIs resistanceexosomalmiR-30a-5pROR1

Identifiers

PMID33952725
PMCPMC8148492

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.