Evidence map›Paper›PMID 33952668›Full record

ArticlemSphere2021

Clearance of Clostridioides difficile Colonization Is Associated with Antibiotic-Specific Bacterial Changes.

Nicholas A Lesniak, Alyxandria M Schubert, Hamide Sinani, Patrick D Schloss

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Dietary iron attenuatesVirulence · 2025
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  5. The state of play of rodent models for the study ofJournal of medical microbiology · 2024
    Review
  6. Article
  7. Reviewing theMicroorganisms · 2024
    Review
  8. Review
  9. Article
  10. Systematic Design of Adenosine Analogs as Inhibitors of aJournal of medicinal chemistry · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Disordered Intestinal Microbial Communities DuringFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nicholas A LesniakDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Alyxandria M SchubertDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Hamide SinaniDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Patrick D SchlossDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA pschloss@umich.edu.ORCID 0000-0002-6935-4275
University of Michigan · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
Systems biology of Clostridium difficile infectionU01AI124255 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHLOSS, PATRICK DAVID, YOUNG, VINCENT B · 2016 to 2020
$9.8M
The Interplay Between Host Immunity and Clostridium difficile PathogenesisU19AI090871 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YOUNG, VINCENT B · 2010 to 2014
$7.5M
Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Diversity and stability relationships in the murine microbiomeR01GM099514 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHLOSS, PATRICK DAVID · 2012 to 2015
$1.4M
NIAID NIH HHS T32 AI007528NIAID NIH HHS U01 AI124255NIAID NIH HHS U19 AI090871NIDDK NIH HHS P30 DK034933NIGMS NIH HHS R01 GM099514
6 · The paper itself

Abstract

The gut bacterial community prevents many pathogens from colonizing the intestine. Previous studies have associated specific bacteria with clearing

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaCefoperazoneClindamycinClostridioides difficileClostridium InfectionsDisease SusceptibilityFecesGastrointestinal MicrobiomeMiceStreptomycinAnti-Bacterial AgentsCefoperazoneClindamycinStreptomycin16S rRNA geneClostridioides difficileClostridium difficilecolonization resistancedynamicsmicrobial ecologymicrobiomemicrobiota

Identifiers

PMID33952668
PMCPMC8103992
OpenAlexW3158607664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.