ArticleDiabetes care2021
Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes.
Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Harnessing Machine Learning, a Subset of Artificial Intelligence, for Early Detection and Diagnosis of Type 1 Diabetes: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine.Scientific reports · 2024Trial
- Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers.Scientific reports · 2022Trial
- Associations between residential greenness, land cover and risk of celiac disease in genetically at-risk children: Celiac Prediction in Skåne study.Journal of pediatric gastroenterology and nutrition · 2026Article
- Neighborhood deadwood and yard rewilding modulate commensal microbiomes and inflammatory signals among urbanites.Microbiome · 2026Article
- Playgrounds as microbial interfaces: strategies to enhance soil microbiomes and support healthy childhoods.mSystems · 2026Review
- Environmental Mechanisms Influencing the Pathogenesis and Progression of Type 1 Diabetes.International journal of molecular sciences · 2025Review
- Can we improve immune health by restoring microbial biodiversity?Nature reviews. Immunology · 2025Article
- Epidemiology of type 1 diabetes in Podlasie region, Poland, in years 2010-2022 - 13-years-single-center study, including COVID-19 pandemic perspective.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Green space quantity and exposure in relation to the risk of immune-mediated diseases: a scoping review.BMC public health · 2024Article
- Using patterns of shared taxa to infer bacterial dispersal in human living environment in urban and rural areas.Applied and environmental microbiology · 2024Article
- Comparison of the effect of autoclaved and non-autoclaved live soil exposure on the mouse immune system : Effect of soil exposure on immune system.BMC immunology · 2023Article
- Residential green environments are associated with human milk oligosaccharide diversity and composition.Scientific reports · 2023Article
- A short history from Karelia study to biodiversity and public health interventions.Frontiers in allergy · 2023Review
- Exposomic determinants of immune-mediated diseases: Special focus on type 1 diabetes, celiac disease, asthma, and allergies: The HEDIMED project approach.Environmental epidemiology (Philadelphia, Pa.) · 2022Review
- Review
- Effect of inactivated nature-derived microbial composition on mouse immune system.Immunity, inflammation and disease · 2022Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEnvironmental microbial exposures have been implicated to protect against immune-mediated diseases such as type 1 diabetes. Our objective was to study the association of land cover around the early-life dwelling with the development of islet autoimmunity and type 1 diabetes to evaluate the role of environmental microbial biodiversity in the pathogenesis. RESEARCH DESIGN AND
methodsAssociation between land cover types and the future risk of type 1 diabetes was studied by analyzing land cover types classified according to Coordination of Information on the Environment (CORINE) 2012 and 2000 data around the dwelling during the first year of life for 10,681 children genotyped for disease-associated HLA-DQ alleles and monitored from birth in the Type 1 Diabetes Prediction and Prevention (DIPP) study. Land cover was compared between children who developed type 1 diabetes (
resultsAgricultural land cover around the home was inversely associated with diabetes risk (odds ratio 0.37, 95% CI 0.16-0.87,
conclusionsThe study suggests that exposure to an agricultural environment (comprising nonirrigated arable land, fruit trees and berry plantations, pastures, natural pastures, land principally occupied by agriculture with significant areas of natural vegetation, and agroforestry areas) early in life is inversely associated with the risk of type 1 diabetes. This association may be mediated by early exposure to environmental microbial diversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.