ReviewEuropean respiratory review : an official journal of the European Respiratory Society2021
Awake prone positioning for hypoxaemic respiratory failure: past, COVID-19 and perspectives.
Review in European respiratory review : an official journal of the European Respiratory Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Prone positioning effect on tracheal intubation rate, mortality and oxygenation parameters in awake non-intubated severe COVID-19-induced respiratory failure: a review of reviews.European journal of medical research · 2024Pooled it
- Awake prone positioning for patients with COVID-19-related respiratory failure: a systematic review and meta-analysis.Internal and emergency medicine · 2024Pooled it
- Effect of Awake Prone Positioning in non-Intubated COVID-19 Patients with Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-Analysis.Journal of intensive care medicine · 2022Pooled it
- Awake Prone-Positioning in Patients on Non-Invasive Ventilation for Management of SARS-CoV-2 Pneumonia: A Systematic Review.Advances in respiratory medicine · 2022Pooled it
- [Efficacy of bronchoalveolar lavage combined with prone positioning in children withZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Trial
- Lung impedance changes during awake prone positioning in COVID-19. A non-randomized cross-over study.PloS one · 2024Trial
- Awake Prone Positioning in Non-Intubated Non-COVID-19 ARDS: A Comprehensive Review.Advances in respiratory medicine · 2026Review
- The experiences of critical care nurses caring for patients undergoing awake prone positioning: a qualitative study.BMC nursing · 2026Article
- Association of awake prone positioning with clinical outcomes in severe immune checkpoint inhibitor-associated pneumonitis with acute hypoxemic respiratory failure: a propensity-matched retrospective cohort study.Frontiers in medicine · 2026Article
- Acute exogenous lipoid pneumonia leading to severe ARDS: a case report.BMC pulmonary medicine · 2025Article
- The effects of different prone ventilation strategies on mechanical power and respiratory mechanics in acute respiratory distress syndrome patients: a prospective, single-center observational study.Journal of thoracic disease · 2025Article
- Prone retroperitoneal robotic-assisted laparoscopic radical nephroureterectomy with bladder cuff excision in single position: techniques and outcomes.Journal of robotic surgery · 2025Article
- Importance of timing and training to implement awake prone positioning in patients with COVID-19: a single-center prospective observational study.Journal of thoracic disease · 2023Article
- Compliance of Prone Positioning in Non-Intubated COVID-19 Patients.Clinical medicine & research · 2023Article
- Review
- Hemodynamic Effects of Awake Prone Positioning With COVID-19 Acute Respiratory Failure.Respiratory care · 2023Article
- Effect of prone position on clinical outcomes of nonintubated patients with COVID-19: A randomised clinical trial.Collegian (Royal College of Nursing, Australia) · 2023Article
- Efficacy and safety of awake prone positioning in the treatment of non-intubated spontaneously breathing patients with COVID-19-related acute respiratory failure: A systematic review and meta-analysis.Journal of intensive medicine · 2023Article
- Highlights from the Respiratory Failure and Mechanical Ventilation 2022 Conference.ERJ open research · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prone positioning reduces mortality in the management of intubated patients with moderate-to-severe acute respiratory distress syndrome. It allows improvement in oxygenation by improving ventilation/perfusion ratio mismatching.Because of its positive physiological effects, prone positioning has also been tested in non-intubated, spontaneously breathing patients, or "awake" prone positioning. This review provides an update on awake prone positioning for hypoxaemic respiratory failure, in both coronavirus disease 2019 (COVID-19) and non-COVID-19 patients. In non-COVID-19 acute respiratory failure, studies are limited to a few small nonrandomised studies and involved patients with different diseases. However, results have been appealing with regard to oxygenation improvement, especially when combined with noninvasive ventilation or high-flow nasal cannula.The recent COVID-19 pandemic has led to a major increase in hospitalisations for acute respiratory failure. Awake prone positioning has been used with the aim to prevent intensive care unit admission and mechanical ventilation. Prone positioning in conscious, non-intubated COVID-19 patients is used in emergency departments, medical wards and intensive care units.Several trials reported an improvement in oxygenation and respiratory rate during prone positioning, but impacts on clinical outcomes, particularly on intubation rates and survival, remain unclear. Tolerance of prolonged prone positioning is an issue. Larger controlled, randomised studies are underway to provide results concerning clinical benefit and define optimised prone positioning regimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.