Evidence map›Paper›PMID 33952541›Full record

ArticleBMJ open2021

Key dimensions of post-traumatic stress disorder and endothelial dysfunction: a protocol for a mechanism-focused cohort study.

Shiloh Cleveland, Kristina Reed, Jordan L Thomas, Olujimi A Ajijola, Ramin Ebrahimi, Tzung Hsiai, Amit Lazarov, Amanda K Montoya, Yuval Neria, Daichi Shimbo and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03778307 (Key Dimensions of Post-traumatic Stress Disorder), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03778307 completednot on this map

Key Dimensions of Post-traumatic Stress Disorder (PTSD) and Endothelial Dysfunction (ED)

TypeobservationalSponsorUniversity of California, Los AngelesRan2019 to 2025Enrolled168ConditionsTrauma, PTSD, Endothelial DysfunctionArmsPsychophysiological fear conditioning and extinction task, Eyetracking task
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. PTSD as an Endothelial Disease: Insights From COVID-19.Frontiers in cellular neuroscience · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Shiloh ClevelandPsychology, University of California Los Angeles, Los Angeles, California, USA.
Kristina ReedPsychology, University of California Los Angeles, Los Angeles, California, USA.
Jordan L ThomasPsychology, University of California Los Angeles, Los Angeles, California, USA.
Olujimi A AjijolaNeurocardiology Research Center of Excellence, Cardiac Arrhythmia Center, University of California Los Angeles, Los Angeles, California, USA.
Ramin EbrahimiMedicine, University of California Los Angeles, Los Angeles, California, USA.
Tzung HsiaiMedicine, University of California Los Angeles, Los Angeles, California, USA.
Amit LazarovSchool of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
Amanda K MontoyaPsychology, University of California Los Angeles, Los Angeles, California, USA.
Yuval NeriaPsychiatry, Columbia University Irving Medical Center, New York, New York, USA.
Daichi ShimboMedicine, Columbia University Irving Medical Center, New York, New York, USA.
Kate Wolitzky-TaylorPsychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
Jennifer A SumnerPsychology, University of California Los Angeles, Los Angeles, California, USA jsumner@psych.ucla.edu.ORCID 0000-0002-0217-7171
University of California, Los Angeles · USColumbia University Irving Medical Center · USTel Aviv University · IL

Funding

Identifying Early Intervention Targets for Reducing Cardiovascular Risk in Posttraumatic StressR01HL139614 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMNER, JENNIFER A · 2018 to 2022
$3.9M
NHLBI NIH HHS R01 HL139614
6 · The paper itself

Abstract

introductionBoth trauma exposure and post-traumatic stress disorder (PTSD) are associated with increased risk of cardiovascular disease (CVD), the leading cause of death in the USA. Endothelial dysfunction, a modifiable, early marker of CVD risk, may represent a physiological mechanism underlying this association. This mechanism-focused cohort study aims to investigate the relationship between PTSD (both in terms of diagnosis and underlying symptom dimensions) and endothelial dysfunction in a diverse, community-based sample of adult men and women. METHODS AND ANALYSIS: Using a cohort design, 160 trauma-exposed participants without a history of CVD are designated to the PTSD group (n=80) or trauma-exposed matched control group (n=80) after a baseline diagnostic interview assessment. Participants in the PTSD group have a current (past month) diagnosis of PTSD, whereas those in the control group have a history of trauma but no current or past psychiatric diagnoses. Endothelial dysfunction is assessed via flow-mediated vasodilation of the brachial artery and circulating levels of endothelial cell-derived microparticles. Two higher order symptom dimensions of PTSD-fear and dysphoria-are measured objectively with a fear conditioning paradigm and attention allocation task, respectively. Autonomic imbalance, inflammation, and oxidative stress are additionally assessed and will be examined as potential pathway variables linking PTSD and its dimensions with endothelial dysfunction. Participants are invited to return for a 2-year follow-up visit to reassess PTSD and its dimensions and endothelial dysfunction in order to investigate longitudinal associations. ETHICS AND DISSEMINATION: This study is conducted in compliance with the Helsinki Declaration and University of California, Los Angeles Institutional Review Board. The results of this study will be disseminated via articles in peer-reviewed journals and presentations at academic conferences and to community partners. TRIAL REGISTRATION NUMBER: NCT03778307; pre-results.

Indexed as

Stress Disorders, Post-TraumaticAdultBrachial ArteryCohort StudiesFearFemaleHumansLos AngelesMaleadult psychiatryanxiety disorderscardiology

Identifiers

PMID33952541
PMCPMC8103395
OpenAlexW3158377903

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.