ReviewJournal of the International Neuropsychological Society : JINS2021
Exercise, Arterial Stiffness, and Cerebral Vascular Function: Potential Impact on Brain Health.
Review in Journal of the International Neuropsychological Society : JINS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Brain function effects of exercise interventions for cognitive decline: a systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Long-term egg-protein hydrolysate consumption improves endothelial function: a randomized, double-blind, placebo-controlled trial in older adults with overweight or obesity.European journal of nutrition · 2024Trial
- Effect of combined physical-cognitive training on the functional and cognitive capacity of older people with mild cognitive impairment: a randomized controlled trial.BMC medicine · 2024Trial
- Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease.GeroScience · 2026Article
- Network outcome analysis of cognitive function and daily functioning and risk of dementia among adults aged 50 years and older: an 8-year prospective study.European archives of psychiatry and clinical neuroscience · 2026Article
- Impact of Invasive Intracranial Pressure Monitoring on Outcomes in Older Adults with Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Neurocritical care · 2026Article
- Exercise Training for Cerebrovascular and Cognitive Health in Adults at Risk of Cognitive Decline: A Scoping Review of Healthcare Translation and Evidence Gaps.Healthcare (Basel, Switzerland) · 2026Review
- Direct Evidence for the Feedforward Neurovascular Coupling Mechanism in Humans During Task Onset: An EEG-fNIRS-TCD Multimodal Imaging Study.Sensors (Basel, Switzerland) · 2026Article
- Chronic Aerobic Exercise Alleviates Amyloid-induced Capillary Dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Cerebral blood flow regulation, central arterial stiffness and traumatic brain injury: Effects of aerobic exercise training.Experimental physiology · 2026Review
- Epigenome-wide exploratory study of blood DNA methylation and markers of physical performance indicates subtle differences across levels of cardiovascular fitness.Frontiers in physiology · 2026Article
- The Endothelium as a Central Mediator of Exercise-Induced Metabolism and Communication.Exercise and sport sciences reviews · 2026Review
- Cerebral Resistance Artery Histological Remodeling After Training-Sex Differences.Life (Basel, Switzerland) · 2025Article
- Uncovering the link between incidental physical activity and inhibition of automatic responses in aging. An ERP study.Frontiers in aging neuroscience · 2025Article
- Health and aging trajectories: shared and competing risks and resiliencies for chronic diseases associated with aging. A NIH-wide workshop.Frontiers in public health · 2025Article
- Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults.Aging and disease · 2024Review
- Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function.Journal of Alzheimer's disease : JAD · 2024Article
- Prestroke physical activity is associated with admission haematoma volume and the clinical outcome of intracerebral haemorrhage.Stroke and vascular neurology · 2023Article
- Roles of physical activity and diet in cognitive aging: is more better?The Clinical neuropsychologist · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Exercise is associated with higher cognitive function and is a promising intervention to reduce the risk of dementia. With advancing age, there are changes in the vasculature that have important clinical implications for brain health and cognition. Primary aging and vascular risk factors are associated with increases in arterial stiffness and pulse pressure, and reductions in peripheral vascular function.
objectiveThe purpose is to discuss the epidemiological, observational, and mechanistic evidence regarding the link between age-related changes in vascular health and brain health.
methodsWe performed a literature review and integrated with our published data.
resultsEpidemiological evidence suggests a link between age-related increases in arterial stiffness and lower cognitive function, which may be mediated by cerebral vascular function, including cerebral vasoreactivity and cerebral pulsatility. Age-associated impairments in central arterial stiffness and peripheral vascular function have been attenuated or reversed through lifestyle behaviors such as exercise. Greater volumes of habitual exercise and higher cardiorespiratory fitness are associated with beneficial effects on both peripheral vascular health and cognition. Yet, the extent to which exercise directly influences cerebral vascular function and brain health, as well as the associated mechanisms remains unclear.
conclusionAlthough there is evidence that exercise positively impacts cerebral vascular function, more research is necessary in humans to optimize experimental protocols and address methodological limitations and physiological considerations. Understanding the impact of exercise on cerebral vascular function is important for understanding the association between exercise and brain health and may inform future intervention studies that seek to improve cognition.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.