ArticleInfection control and hospital epidemiology2022
Secondary attack rates from asymptomatic and symptomatic influenza virus shedders in hospitals: Results from the TransFLUas influenza transmission study.
Article in Infection control and hospital epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Strategies for Preventing Nosocomial Influenza in Acute-Care Hospitals: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Incidence of laboratory-confirmed influenza and RSV and associated presenteeism and absenteeism among healthcare personnel, Israel, influenza seasons 2016 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- The role of asymptomatic infections in influenza transmission: what do we really know.The Lancet. Infectious diseases · 2024Review
- Respiratory virus infections in symptomatic and asymptomatic children upon hospital admission: new insights.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Article
- Droplet precautions on-site (DroPS) during the influenza season 2018/2019: a possible alternative to single room isolation for respiratory viral infections.Antimicrobial resistance and infection control · 2022Article
- Rate of diagnosed seasonal influenza in children with influenza-like illness: A cross-sectional study.PloS one · 2022Article
- Influenza Vaccination Programs for Healthcare Personnel: Organizational Issues and Beyond.International journal of environmental research and public health · 2021Article
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Authors and funding
21 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNosocomial transmission of influenza is a major concern for infection control. We aimed to dissect transmission dynamics of influenza, including asymptomatic transmission events, in acute care.
designProspective surveillance study during 2 influenza seasons.
settingTertiary-care hospital.
participantsVolunteer sample of inpatients on medical wards and healthcare workers (HCWs).
methodsParticipants provided daily illness diaries and nasal swabs for influenza A and B detection and whole-genome sequencing for phylogenetic analyses. Contacts between study participants were tracked. Secondary influenza attack rates were calculated based on spatial and temporal proximity and phylogenetic evidence for transmission.
resultsIn total, 152 HCWs and 542 inpatients were included; 16 HCWs (10.5%) and 19 inpatients (3.5%) tested positive for influenza on 109 study days. Study participants had symptoms of disease on most of the days they tested positive for influenza (83.1% and 91.9% for HCWs and inpatients, respectively). Also, 11(15.5%) of 71 influenza-positive swabs among HCWs and 3 (7.9%) of 38 influenza-positive swabs among inpatients were collected on days without symptoms; 2 (12.5%) of 16 HCWs and 2 (10.5%) of 19 inpatients remained fully asymptomatic. The secondary attack rate was low: we recorded 1 transmission event over 159 contact days (0.6%) that originated from a symptomatic case. No transmission event occurred in 61 monitored days of contacts with asymptomatic influenza-positive individuals.
conclusionsInfluenza in acute care is common, and individuals regularly shed influenza virus without harboring symptoms. Nevertheless, both symptomatic and asymptomatic transmission events proved rare. We suggest that healthcare-associated influenza prevention strategies that are based on preseason vaccination and barrier precautions for symptomatic individuals seem to be effective.
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